Pd(II)-Catalyzed ortho-Trifluoromethylation of Arenes Using TFA as a Promoter

被引：456

作者：

Wang, Xisheng ^{[1
]}

Truesdale, Larry ^{[2
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Pfizer Inc, La Jolla Labs, Dept External R&D Innovat, San Diego, CA 92121 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 11期

基金：

美国国家科学基金会;

关键词：

MEDICINAL CHEMISTRY; ORGANIC HALIDES; BOND FORMATION; PALLADIUM; FLUORINE; PD; COMPLEXES; ALDEHYDES; ALKYNES; AGENTS;

D O I：

10.1021/ja909522s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Pd(II)-catalyzed C-H activation/trifluoromethylation of arenes with an electrophilic trifluoromethylation reagent using diverse heterocycle directing groups is reported. The presence of trifluoroacetic acid is crucial for this catalytic reaction.

引用

页码：3648 / +

页数：4

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