Psychostimulants and brain dysfunction: A review of the relevant neurotoxic effects

被引:47
作者
Goncalves, Joana [1 ]
Baptista, Sofia [1 ]
Silva, Ana Paula [1 ]
机构
[1] Univ Coimbra, Fac Med, Inst Biomed Imaging & Life Sci IBILI, Lab Pharmacol & Expt Therapeut, P-3000548 Coimbra, Portugal
关键词
Psychostimulants; Neurotoxicity; Neuroinflammation; Blood-brain barrier; Neurogenesis; MITOCHONDRIAL RESPIRATORY-CHAIN; METHAMPHETAMINE-INDUCED HYPERTHERMIA; INDUCED DOPAMINERGIC NEUROTOXICITY; ADULT HIPPOCAMPAL NEUROGENESIS; CONDITIONED PLACE PREFERENCE; INCREASED OXIDATIVE STRESS; MESSENGER-RNA EXPRESSION; RECEPTOR SUBUNIT LEVELS; LONG-TERM POTENTIATION; CORE BODY-TEMPERATURE;
D O I
10.1016/j.neuropharm.2014.01.006
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Psychostimulants abuse is a major public concern because is associated with serious health complications, including devastating consequences on the central nervous system (CNS). The neurotoxic effects of these drugs have been extensively studied. Nevertheless, numerous questions and uncertainties remain in our understanding of these toxic events. Thus, the purpose of the present manuscript is to review cellular and molecular mechanisms that might be responsible for brain dysfunction induced by psychostimulants. Topics reviewed include some classical aspects of neurotoxicity, such as monoaminergic system and mitochondrial dysfunction, oxidative stress, excitotoxicity and hyperthermia. Moreover, recent literature has suggested new phenomena regarding the toxic effects of psychostimulants. Thus, we also reviewed the impact of these drugs on neuroinflammatory response, blood-brain barrier (BBB) function and neurogenesis. Assessing the relative importance of these mechanisms on psychostimulants-induced brain dysfunction presents an exciting challenge for future research efforts. This article is part of the Special Issue entitled 'CNS Stimulants'. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:135 / 149
页数:15
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