New Thermo-Sensitive Graft Copolymers Based on a Poly(N-isopropylacrylamide) Backbone and Functional Polyoxazoline Grafts with Random and Diblock Structure

被引：27

作者：

Carlos Rueda, Juan ^{[2
]}

Zschoche, Stefan ^{[1
]}

Komber, Hartmut ^{[1
]}

Krahl, Franziska ^{[3
]}

Arndt, Karl-Friedrich ^{[3
]}

Voit, Brigitte ^{[1
]}

机构：

[1] Leibniz Inst Polymer Res Dresden, D-01069 Dresden, Germany

[2] Pontificia Univ Catolica Peru, DAI, Secc Fis, Lab Polimeros, Lima, Peru

[3] Tech Univ Dresden, D-01062 Dresden, Germany

来源：

MACROMOLECULAR CHEMISTRY AND PHYSICS | 2010年 / 211卷 / 06期

关键词：

functionalization of polymers; graft copolymer; micelles; self-organization; stimuli-sensitive polymers; CRITICAL SOLUTION TEMPERATURE; RESPONSIVE POLYMERS; BLOCK-COPOLYMERS; DRUG-DELIVERY; POLYMERIZATION; WATER; NANOPARTICLES; MICELLES; ACID); LCST;

D O I：

10.1002/macp.200900437

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

New thermo-sensitive functionalized graft copolymers characterized by a poly(N-isopropylacrylamide) backbone and grafts containing 2-ethyl-2-oxazoline and 2-(2-methoxycarbonyl-ethyl)-2-oxazoline units were synthesized. The conformation transition temperatures of the graft copolymers could be modified by variation of the molar composition in the side chain, by different side chain structure (random distribution of both oxazolines vs. diblock structure) and by hydrolysis of the methylester to the acid form. Graft copolymers with long functional oxazoline side chains allowed the stabilization of aggregates above the phase transition temperature of the backbone until the LCST of the side chain. The temperature window allowing for the formation of stable aggregates was widened with acid functions in the corona.

引用

页码：706 / 716

页数：11

共 25 条

[1] Stimuli responsive polymers for biomedical applications
Alarcón, CDH
Pennadam, S
Alexander, C
[J]. CHEMICAL SOCIETY REVIEWS, 2005, 34 (03) : 276 - 285
[2] [Anonymous], 1991, Laser light scattering
[3] Polymerization of oxazolines
Aoi, K
Okada, M
[J]. PROGRESS IN POLYMER SCIENCE, 1996, 21 (01) : 151 - 208
[4] GRAFT-COPOLYMERS THAT EXHIBIT TEMPERATURE-INDUCED PHASE-TRANSITIONS OVER A WIDE-RANGE OF PH
CHEN, GH
HOFFMAN, AS
[J]. NATURE, 1995, 373 (6509) : 49 - 52
[5] Poly(N-isopropylacrylamide) grafted to a strongly charged backbone:: Thermoresponsive behavior in aqueous solution
Chourdakis, N
Bokias, G
Staikos, G
[J]. JOURNAL OF APPLIED POLYMER SCIENCE, 2004, 92 (06) : 3466 - 3470
[6] New thermo-responsive polymer materials based on poly(2-ethyl-2-oxazoline) segments
Christova, D
Velichkova, R
Loos, W
Goethals, EJ
Du Prez, F
[J]. POLYMER, 2003, 44 (08) : 2255 - 2261
[7] Thermo-Responsive Polyoxazolines with Widely Tuneable LCST
Diehl, Christina
Schlaad, Helmut
[J]. MACROMOLECULAR BIOSCIENCE, 2009, 9 (02) : 157 - 161
[8] Thermosensitive water-soluble copolymers with doubly responsive reversibly interacting entities
Dimitrov, Ivaylo
Trzebicka, Barbara
Muller, Axel H. E.
Dworak, Andrzej
Tsvetanov, Christo B.
[J]. PROGRESS IN POLYMER SCIENCE, 2007, 32 (11) : 1275 - 1343
[9] Tuning the LCST of poly(2-oxazoline)s by varying composition and molecular weight: alternatives to poly(N-isopropylacrylamide)?
Hoogenboom, Richard
Thijs, Hanneke M. L.
Jochems, Mark J. H. C.
van Lankvelt, Bart M.
Fijten, Martin W. M.
Schubert, Ulrich S.
[J]. CHEMICAL COMMUNICATIONS, 2008, (44) : 5758 - 5760
[10] Environmental-sensitive micelles based on poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) diblock copolymer for application in drug delivery
Hsiue, Ging-Ho
Wang, Chun-Hung
Lo, Chun-Liang
Wang, Chau-Hui
Li, Ju-Pi
Yang, Jia-Ling
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2006, 317 (01) : 69 - 75

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