Suppression of nanoparticle cytotoxicity approaching in vivo serum concentrations: limitations of in vitro testing for nanosafety

被引：84
作者：
Kim, Jong Ah
Salvati, Anna
Aberg, Christoffer
Dawson, Kenneth A.
机构：
[1] Natl Univ Ireland Univ Coll Dublin, Ctr BioNano Interact, Sch Chem & Chem Biol, Dublin 4, Ireland
[2] Natl Univ Ireland Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dublin 4, Ireland
来源：
NANOSCALE | 2014年 / 6卷 / 23期
基金：
爱尔兰科学基金会;
关键词：
PROTEIN CORONA; CELL-MEMBRANE; PLASMA; NANOTECHNOLOGY; TOXICITY; IMPACT;
D O I：
10.1039/c4nr04970e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Nanomaterials challenge paradigms of in vitro testing because unlike molecular species, biomolecules in the dispersion medium modulate their interactions with cells. Exposing cells to nanoparticles known to cause cell death, we observed cytotoxicity suppression by increasing the amount of serum in the dispersion medium towards in vivo-relevant conditions.
引用
收藏
页码：14180 / 14184
页数：5
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