Pancreatic IL-10 induces diabetes in NOD, B6 Idd3 Idd10 mice

被引：7
作者：
Lee, MS [1 ]
Wicker, LS [1 ]
Peterson, LB [1 ]
Sarvetnick, N [1 ]
机构：
[1] Scripps Res Inst, Dept Neuropharmacol, La Jolla, CA 92037 USA
来源：
AUTOIMMUNITY | 1997年 / 26卷 / 04期
关键词：
pancreatic IL-10; induces diabetes; Idd3; Idd10; mice;
D O I：
10.3109/08916939709008027
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Transgenic NOD backcross mice expressing pancreatic interleukin 10 (IL-10) were crossed and backcrossed to NOD.B6 Idd3 Idd10 mice, which have diabetes-resistance alleles at Idd3 and Idd10 on chromosome 3 and have a very low frequency diabetes and insulitis. Insulitis and diabetes developed in almost all IL-10 transgenic backcross 1 (BC1) mice of the H2g(7/g7) haplotype regardless of the allelic status at Idd3 and Idd10. Furthermore, diabetes occurred in 23% of IL-10 transgenic H2g(7/d) BC1 mice. These results indicate that pancreatic IL-10 is able to overcome the diabetes protection afforded by C57BL/6 (B6)-derived alleles at Idd3 and Idd10 as well as the absence of NOD MHC homozygosity, if other non-MHC NOD-derived Idd alleles are provided.
引用
收藏
页码：215 / 221
页数：7
相关论文
共 23 条
  • [1] AITMAN TJ, 1991, MAMM GENOME, V1, P273
  • [2] GENETIC REQUIREMENTS FOR ACCELERATION OF DIABETES IN NONOBESE DIABETIC MICE EXPRESSING INTERLEUKIN-2 IN ISLET BETA-CELLS
    ALLISON, J
    MCCLIVE, P
    OXBROW, L
    BAXTER, A
    MORAHAN, G
    MILLER, JFAP
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (10) : 2535 - 2541
  • [3] INTERLEUKIN-10 AND TRANSFORMING GROWTH-FACTOR-BETA COOPERATE TO INDUCE ANTI-CD40 ACTIVATED NAIVE HUMAN B-CELLS TO SECRETE IMMUNOGLOBULIN-A
    DEFRANCE, T
    VANBERVLIET, B
    BRIERE, F
    DURAND, I
    ROUSSET, F
    BANCHEREAU, J
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (03) : 671 - 682
  • [4] DING L, 1993, J IMMUNOL, V151, P1224
  • [5] DING L, 1992, J IMMUNOL, V148, P3133
  • [6] GIOVARELLI M, 1995, J IMMUNOL, V155, P3112
  • [7] INTERLEUKIN-10, A NOVEL B-CELL STIMULATORY FACTOR - UNRESPONSIVENESS OF X-CHROMOSOME LINKED IMMUNODEFICIENCY-B CELLS
    GO, NF
    CASTLE, BE
    BARRETT, R
    KASTELEIN, R
    DANG, W
    MOSMANN, TR
    MOORE, KW
    HOWARD, M
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (06) : 1625 - 1631
  • [8] ADDITIONAL MICROSATELLITE MARKERS FOR MOUSE GENOME MAPPING
    HEARNE, CM
    MCALEER, MA
    LOVE, JM
    AITMAN, TJ
    CORNALL, RJ
    GHOSH, S
    KNIGHT, AM
    PRINS, JB
    TODD, JA
    [J]. MAMMALIAN GENOME, 1991, 1 (04) : 273 - 282
  • [9] CONTINUOUS ADMINISTRATION OF ANTI-INTERLEUKIN-10 ANTIBODIES DELAYS ONSET OF AUTOIMMUNITY IN NZB/W F1-MICE
    ISHIDA, H
    MUCHAMUEL, T
    SAKAGUCHI, S
    ANDRADE, S
    MENON, S
    HOWARD, M
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (01) : 305 - 310
  • [10] IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity
    Lee, MS
    Mueller, R
    Wicker, LS
    Peterson, LB
    Sarvetnick, N
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (06) : 2663 - 2668
123