Synthesis of certain new pyridine derivatives as potential radioprotective and cytotoxic agents

被引：0
|
作者：
Hassan, AY
Ghorab, MM
Nassar, OM
机构：
[1] Al Azhar Univ, Fac Sci, Dept Chem, Girls Branch, Cairo, Egypt
[2] Atom Energy Author, Natl Ctr Radiat Res & Technol, Dept Drug Radiat Res, Cairo, Egypt
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 7卷 / 02期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A number of pyridines derived from 2-phenyl-4-methyl-1,2-dihydro-6-oxo-5-pyridinecarbonitrile (3) have been synthesized and evaluated for radioprotection and cytotoxic activities. The structures are supported by elemental and spectral analyses. Most of the tested compounds displayed significant activity as cytotoxic and/or radioprotectors.
引用
收藏
页码：129 / 134
页数：6
相关论文
共 50 条
  • [21] Synthesis and Cytotoxic Evaluation of Acylated Brefeldin A Derivatives as Potential Anticancer Agents
    He, Bingyong
    Wang, Yajun
    Zheng, Yuguo
    Chen, Wei
    Zhu, Qing
    CHEMICAL BIOLOGY & DRUG DESIGN, 2013, 82 (03) : 307 - 316
  • [22] Synthesis and bioactivity evaluation of pachymic acid derivatives as potential cytotoxic agents
    Wang, Hezhen
    Sun, Xun
    Wei, Chunyong
    Wang, Jing
    Xu, Yingshu
    Bai, Guohui
    Yao, Qizheng
    Zhang, Lei
    MEDICINAL CHEMISTRY RESEARCH, 2023, 32 (02) : 342 - 354
  • [23] Synthesis and bioactivity evaluation of pachymic acid derivatives as potential cytotoxic agents
    Hezhen Wang
    Xun Sun
    Chunyong Wei
    Jing Wang
    Yingshu Xu
    Guohui Bai
    Qizheng Yao
    Lei Zhang
    Medicinal Chemistry Research, 2023, 32 : 342 - 354
  • [24] SEARCH FOR NEW RADIOPROTECTIVE AGENTS .19. SYNTHESIS OF SOME SULFIDES OF QUINAZOLINE DERIVATIVES
    TULECKI, J
    KALINOWS.J
    DISSERTATIONES PHARMACEUTICAE ET PHARMACOLOGICAE, 1970, 22 (01): : 21 - &
  • [25] SYNTHESIS OF CERTAIN TRICYCLIC QUINOLINE DERIVATIVES AS POTENTIAL ANTIAMEBAL AGENTS (1)
    CANNON, JG
    LAZARIS, SA
    WUNDERLICH, TA
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1967, 4 (02) : 259 - +
  • [26] SYNTHESIS OF CERTAIN 2-AMINOADAMANTANE DERIVATIVES AS POTENTIAL ANTIMICROBIAL AGENTS
    EISA, HM
    TANTAWY, AS
    ELKERDAWY, MM
    PHARMAZIE, 1991, 46 (03): : 182 - 184
  • [27] Synthesis of certain pyridine derivatives of barbituric acid
    Kuhn, CS
    Richter, GH
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1935, 57 : 1927 - 1929
  • [28] Synthesis, characterization and cytotoxic activity of new salicylaldehyde benzoylhydrazone derivatives as potential anti-proliferative agents
    Nikolova-Mladenova, Boriana
    Halachev, Nenko
    Iankova, Rumjana
    Momekov, Georgi
    Ivanov, Darvin
    ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 2011, 61 (12): : 714 - 718
  • [29] SYNTHESIS OF NITROSOUREA DERIVATIVES OF PYRIDINE AND PIPERIDINE AS POTENTIAL ANTI-CANCER AGENTS
    CRIDER, AM
    LAMEY, R
    FLOSS, HG
    CASSADY, JM
    JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (08) : 848 - 851
  • [30] Synthesis and Evaluation of Thiazole – Pyrimidine Derivatives as New Anticandidal and Cytotoxic Agents
    Gülhan Turan-Zitouni
    Mehlika Dilek Altıntop
    Zafer Asım Kaplancıklı
    Ahmet Özdemir
    Fatih Demirci
    Sinem Ilgın
    Özlem Atlı
    Gamze Göger
    Pharmaceutical Chemistry Journal, 2014, 48 : 452 - 455
12345