Role of apoptosis in common variable immunodeficiency and selective immunoglobulin A deficiency

被引：43

作者：

Yazdani, Reza ^{[1
,2
]}

Fatholahi, Maryam ^{[3
]}

Ganjalikhani-Hakemi, Mazdak ^{[1
]}

Abolhassani, Hassan ^{[2
,4
]}

Azizi, Gholamreza ^{[5
]}

Hamid, Kabir Magaji ^{[6
,7
]}

Rezaei, Nima ^{[8
]}

Aghamohammadi, Asghar ^{[2
]}

机构：

[1] Isfahan Univ Med Sci, Sch Med, Dept Immunol, Esfahan, Iran

[2] Univ Tehran Med Sci, Childrens Med Ctr, Pediat Ctr Excellence, Res Ctr Immunodeficiencies, Tehran, Iran

[3] Univ Isfahan, Fac Sci, Dept Biol, Esfahan, Iran

[4] Karolinska Univ Hosp Huddinge, Karolinska Inst, Dept Lab Med, Div Clin Immunol, Stockholm, Sweden

[5] Alborz Univ Med Sci, Imam Hassan Mojtaba Hosp, Karaj, Iran

[6] TUMS IC, Sch Publ Hlth, Dept Immunol, Tehran, Iran

[7] Usmanu Danfodiyo Univ, Fac Med Lab Sci, Dept Immunol, Sokoto, Nigeria

[8] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

来源：

MOLECULAR IMMUNOLOGY | 2016年 / 71卷

关键词：

Common variable immunodeficiency; IgA deficiency; Apoptosis; MEMORY B-CELLS; FAS-MEDIATED APOPTOSIS; DIMINISHED CD38 EXPRESSION; UNDERGO ENHANCED APOPTOSIS; CLASS SWITCH RECOMBINATION; 13-CIS RETINOIC ACID; IGA DEFICIENCY; IMMUNE-DEFICIENCY; T-LYMPHOCYTES; IN-VITRO;

D O I：

10.1016/j.molimm.2015.12.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Common variable immunodeficiency (CVID) and selective IgA deficiency (SIgAD) are the most common primary immunodeficiencies in human. Both diseases share clinical manifestation and molecular defects. Increased apoptosis may be one of the mechanisms involved in the pathogenesis of CVID and SIgAD. Elevated apoptosis in this disorder leads to defective long-term survival of B-cells, reduced antibody production, decreased lymphocyte proliferation and defective cytokine secretion. For the first time, we reviewed the role of apoptosis in CVID and SIgAD. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：1 / 9

页数：9

共 127 条

[1] 13-CIS RETINOIC ACID ENHANCES INVIVO LYMPHOCYTE-B DIFFERENTIATION IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY [J].