The epidemiological characteristics of enterovirus infection before and after the use of enterovirus 71 inactivated vaccine in Kunming, China

被引：51

作者：

Jiang, Hongchao ^{[1
,2
,3
,5
]}

Zhang, Zhen ^{[2
,3
,5
]}

Rao, Qing ^{[2
,3
,5
,6
]}

Wang, Xiaodan ^{[1
,4
]}

Wang, Meifen ^{[2
,3
,5
]}

Du, Tingyi ^{[2
,3
,5
]}

Tang, Jiaolian ^{[2
,3
,5
]}

Long, Shuying ^{[2
,3
,5
]}

Zhang, Juan ^{[1
,4
]}

Luo, Jia ^{[1
,4
]}

Pan, Yue ^{[1
,4
]}

Chen, Junying ^{[1
,4
]}

Ma, Jing ^{[2
,3
,5
]}

Liu, Xiaomei ^{[2
,3
,5
]}

Fan, Mao ^{[2
,3
,5
]}

Zhang, Tiesong ^{[2
,3
,5
]}

Sun, Qiangming ^{[1
,4
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biol, Kunming 650118, Yunnan, Peoples R China

[2] Kunming Med Univ, Affiliated Childrens Hosp, Kunming Childrens Hosp, Kunming 650228, Yunnan, Peoples R China

[3] Inst Pediat Dis Res Yunnan, Kunming 650228, Yunnan, Peoples R China

[4] Yunnan Key Lab Vaccine Res & Dev Severe Infect Di, Kunming, Yunnan, Peoples R China

[5] Yunnan Key Lab Childrens Major Dis Res, Kunming, Yunnan, Peoples R China

[6] Guangzhou Med Univ, Affiliated Hosp 1, State Key Lab Resp Dis, Natl Clin Res Ctr Resp Dis,Guangzhou Inst Resp Hl, Guangzhou, Peoples R China

来源：

EMERGING MICROBES & INFECTIONS | 2021年 / 10卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Hand-foot-and-mouth disease; enterovirus A71 vaccine; surveillance; epidemiological characteristics; pathogen spectrum; MOUTH-DISEASE; COXSACKIEVIRUS A6; SEVERE HAND; FOOT; OUTBREAK; A10;

D O I：

10.1080/22221751.2021.1899772

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Enterovirus A71 (EV-A71) inactivated vaccines have been widely inoculated among children in Kunming City after it was approved. However, there was a large-scale outbreak of Enteroviruses (EVs) infection in Kunming, 2018. The epidemiological characteristics of HFMD and EVs were analysed during 2008-2018, which are before and three years after EV-A71 vaccine starting to use. The changes in infection spectrum were also investigated, especially for severe HFMD in 2018. The incidence of EV-A71 decreased dramatically after the EV-A71 vaccine starting use. The proportion of non-CV-A16/EV-A71 EVs positive patients raised to 77.17-85.82%, while, EV-A71 and CV-A16 only accounted for 3.41-7.24% and 6.94-19.42% in 2017 and 2018, respectively. CV-A6 was the most important causative agent in all clinical symptoms (severe HFMD, HFMD, Herpangina and fever), accounting from 42.13% to 62.33%. EV-A71 only account for 0.36-2.05%. In severe HFMD, CV-A6 (62.33%), CV-A10 (11.64%), and CV-A16 (10.96%) were the major causative agent in 2018. EV-A71 inactivated vaccine has a good protective effect against EV-A71 and induced EVs infection spectrum changefully. EV-A71 vaccine has no or insignificant cross-protection effect on CV-A6, CV-A10, and CV-A16. Herein, developing 4-valent combined vaccines is urgently needed.

引用

页码：619 / 628

页数：10

共 29 条

[1] ENTEROVIRUS-71 INFECTIONS AND NEUROLOGIC DISEASE - UNITED-STATES, 1977-1991 [J].