Metal chelating systems synthesized using the copper(I) catalyzed azide-alkyne cycloaddition

被引：378

作者：

Struthers, Harriet ^{[1
]}

Mindt, Thomas L. ^{[2
]}

Schibli, Roger ^{[1
]}

机构：

[1] ETH, Dept Chem & Appl Biosci, Inst Pharmaceut Sci, CH-8093 Zurich, Switzerland

[2] Univ Basel Hosp, Div Radiol Chem, CH-4031 Basel, Switzerland

来源：

DALTON TRANSACTIONS | 2010年 / 39卷 / 03期

关键词：

CROSS-COUPLING REACTIONS; CHIRAL FERROCENYL PHOSPHINES; CLICK-TO-CHELATE; 1,3-DIPOLAR CYCLOADDITION; TERMINAL ALKYNES; IN-VITRO; GOLD NANOPARTICLES; STRUCTURAL-CHARACTERIZATION; RUTHENIUM(II) COMPLEXES; HUISGEN CYCLOADDITION;

D O I：

10.1039/b912608b

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The copper(I) catalyzed azide-alkyne cycloaddition (CuAAC) is the premier example of a click reaction. The reaction is modular, reliable and easy to perform, providing easy access to molecular diversity. The majority of reported applications of the reaction employ the 1,2,3-triazole as a stable linkage to connect two chemical/biological components, while the potential for metal coordination of the heterocycle itself has received much less attention. In fact, 1,4-functionalized 1,2,3-triazoles are versatile ligands offering several donor sites for metal coordination, including N3, N2 and C5. In this article, we summarize the areas in which the CuAAC has been applied to the synthesis of novel triazole-containing ligands for transition metals.

引用

页码：675 / 696

页数：22

共 144 条

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