Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas

被引：98

作者：

Kanai, Motoshi ^{[1
,2
]}

Hamada, Jun-Ichi ^{[1
]}

Takada, Minoru ^{[1
,2
]}

Asano, Toshimichi ^{[1
,2
]}

Murakawa, Katsuhiko ^{[1
,2
]}

Takahashi, Yoko ^{[1
]}

Murai, Taichi ^{[1
]}

Tada, Mitsuhiro ^{[1
]}

Miyamoto, Masaki ^{[2
]}

Kondo, Satoshi ^{[2
]}

Moriuchi, Tetsuya ^{[1
]}

机构：

[1] Hokkaido Univ, Inst Med Genet, Div Canc Related Genes, Kita Ku, Sapporo, Hokkaido 0600815, Japan

[2] Hokkaido Univ, Grad Sch Med, Dept Surg Oncol, Div Canc Med,Kita Ku, Sapporo, Hokkaido 0600815, Japan

来源：

ONCOLOGY REPORTS | 2010年 / 23卷 / 03期

关键词：

HOX; colorectal carcinoma; hepatocellular carcinoma; metastasis; SQUAMOUS-CELL CARCINOMA; CANCER CELLS; LUNG-CANCER; A549; CELLS; HOMEOBOX; HYPERMETHYLATION; INACTIVATION; PATHWAYS; MOTILITY; REGION;

D O I：

10.3892/or_00000706

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

HOX genes are known its master regulator genes which give cells positional information in embryogenesis. In this Study, we compared the expression patterns of 39 HOX genes among human colorectal carcinomas front the right large intestine (cecum, ascending and transverse colon), those from the left large intestine (discending and sigmoid colon, and rectum) and hepatocellular carcinoma. The expression levels of each HOX gene were quantified by analysis based on the real-time RT-PCR. The expression patterns of HOX genes in colorectal and hepatocellular carcinoma tissues differed from those in their normal or non-cancerous tissues. Between the tumor tissues in the right-side large intestine and those in the left-side. different HOX genes were expressed in association with cancer. Further, the expression levels of HOXD8 in liver-metastatic tissues of colorectal carcinomas were as low as in non-cancerous liver tissues, and were significantly lower than those in the primary tissues. These results suggest that dysregulated expressions of HOX genes play all important role in carcinogenesis and malignant progression of colorectal and hepatocellular carcinomas.

引用

页码：843 / 851

页数：9

共 41 条

[1]

Abe M, 2006, ONCOL REP, V15, P797

[2] Clinical significance of promoter hypermethylation of RASSF1A, RARβ2, BRCA1 and HOXA5 in breast cancers of Indian patients [J].

Bagadi, Sarangadhara Appala Raju ;

Prasad, Chandra Prakash ;

Kaur, Jatinder ;

Srivastava, Anurag ;

Prashad, Rajinder ;

Gupta, Siddartha Datta ;

Ralhan, Ranju .

LIFE SCIENCES, 2008, 82 (25-26) :1288-1292

[3]

Breivik J, 1997, INT J CANCER, V74, P664, DOI 10.1002/(SICI)1097-0215(19971219)74:6<664::AID-IJC18>3.0.CO

[4]

2-5

[5] HOX GENE-EXPRESSION IN NORMAL AND NEOPLASTIC HUMAN KIDNEY [J].

CILLO, C ;

BARBA, P ;

FRESCHI, G ;

BUCCIARELLI, G ;

MAGLI, MC ;

BONCINELLI, E .

INTERNATIONAL JOURNAL OF CANCER, 1992, 51 (06) :892-897

[6]

DELATTRE O, 1989, LANCET, V2, P353

[7] EXPRESSION OF HOMEOBOX-CONTAINING GENES IN PRIMARY AND METASTATIC COLORECTAL-CANCER [J].

DEVITA, G ;

BARBA, P ;

ODARTCHENKO, N ;

GIVEL, JC ;

FRESCHI, G ;

BUCCIARELLI, G ;

MAGLI, MC ;

BONCINELLI, E ;

CILLO, C .

EUROPEAN JOURNAL OF CANCER, 1993, 29A (06) :887-893

[8] THE HOX-4.8 GENE IS LOCALIZED AT THE 5' EXTREMITY OF THE HOX-4 COMPLEX AND IS EXPRESSED IN THE MOST POSTERIOR PARTS OF THE BODY DURING DEVELOPMENT [J].

DOLLE, P ;

IZPISUABELMONTE, JC ;

BONCINELLI, E ;

DUBOULE, D .

MECHANISMS OF DEVELOPMENT, 1991, 36 (1-2) :3-13

[9] HOXA5 regulates hMLH1 expression in breast cancer cells [J].

Duriseti, Sai ;

Winnard, Paul T., Jr. ;

Mironchik, Yelena ;

Vesuna, Farhad ;

Raman, Ana ;

Raman, Venu .

NEOPLASIA, 2006, 8 (04) :250-258

[10] HOMEOTIC GENES AND THE HOMEOBOX [J].

GEHRING, WJ ;

HIROMI, Y .

ANNUAL REVIEW OF GENETICS, 1986, 20 :147-173

← 1 2 3 4 5 →