The effect of GABAergic system activity on hyperthermia-induced seizures in rats

被引：11
|
作者：
Fukuda, M [1 ]
Morimoto, T [1 ]
Nagao, H [1 ]
Kida, K [1 ]
机构：
[1] Ehime Univ, Sch Med, Dept Pediat, Shigenobu, Ehime 79102, Japan
来源：
DEVELOPMENTAL BRAIN RESEARCH | 1997年 / 104卷 / 1-2期
关键词：
hyperthermia; GABA; thiosemicarbazide; bicuculine; muscimol; seizure; threshold; duration; adenosine;
D O I：
10.1016/S0165-3806(97)00157-0
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Developing rats were given GABA antagonists and agonist before electrical seizure discharges were induced by heating the brain of a rat with infra-red rays. The thresholds for the GABA antagonist groups were significantly lower than that for the control, and the threshold for the GABA agonist group was significantly higher than that for the control These results support the hypothesis that reduced GABAergic system activity underlies febrile seizures. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：197 / 199
页数：3
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