Multiple myeloma: Evolving genetic events and host interactions

被引：637
作者：
Kuehl, WM
Bergsagel, PL
机构：
[1] Bethesda Naval Hosp, Genet Branch, Ctr Canc Res, NCI,NIH, Bethesda, MD 20889 USA
[2] Cornell Univ, Weill Med Coll, New York, NY 10021 USA
来源：
NATURE REVIEWS CANCER | 2002年 / 2卷 / 03期
关键词：
D O I：
10.1038/nrc746
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Multiple myeloma is a neoplasm of terminally differentiated B cells (plasma cells) in which chromosome translocations frequently place oncogenes under the control of immunoglobulin enhancers. Unlike most haematopoietic cancers, multiple myeloma often has complex chromosomal abnormalities that are reminiscent of epithelial tumours. What causes full-blown myeloma? And can our molecular understanding of this common haematological malignancy be used to develop effective preventive and treatment strategies?
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页码：175 / 187
页数：13
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