Mushroom extract inhibits ultraviolet B-induced cellular senescence in human keratinocytes

被引:4
|
作者
Chong, Zhao [1 ]
Matsuo, Haruka [1 ]
Kuroda, Mai [1 ]
Yamashita, Shuntaro [1 ]
Parajuli, Gopal Prasad [2 ]
Manandhar, Hira Kaji [2 ]
Shimizu, Kuniyoshi [3 ]
Katakura, Yoshinori [3 ]
机构
[1] Kyushu Univ, Grad Sch Syst Life Sci, Higashi Ku, 6-10-1 Hakozaki, Fukuoka, Fukuoka 8128581, Japan
[2] Nepal Agr Res Council, Plant Pathol Div, POB 3605, Kathmandu, Nepal
[3] Kyushu Univ, Fac Agr, Higashi Ku, 6-10-1 Hakozaki, Fukuoka, Fukuoka 8128581, Japan
关键词
SIRT1; Mushroom; Cellular senescence; Keratinocytes; Skin; Ultraviolet B; OXIDATIVE STRESS; VITAMIN D-2; HUMAN SKIN; UVB; CELLS; SIRT1; EXPRESSION; DAMAGE; ANTIOXIDANT; FIBROBLAST;
D O I
10.1007/s10616-018-0229-1
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Mushrooms possess various bioactivities and are used as nutritional supplements and medicinal products. Twenty-nine bioactive components have been extracted recently from mushrooms grown in Nepal. In this study, we evaluated the ability of these mushroom extracts to augment SIRT1, a mammalian SIR2 homologue localized in cytosol and nuclei. We established a system for screening food ingredients that augment the SIRT1 promoter in HaCaT cells, and identified a SIRT1-augmenting mushroom extract (number 28, Trametes versicolor). UVB irradiation induced cellular senescence in HaCaT cells, as evidenced by increased activity and expression of cellular senescence markers including senescence-associated beta-galactosidase, p21, p16, phosphorylated p38, and gamma H2AX. Results clearly showed that the mushroom extract (No. 28) suppressed the ultraviolet B irradiation-induced cellular senescence in HaCaT cells possibly through augmenting SIRT1 expression.
引用
收藏
页码:1001 / 1008
页数:8
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