Extranodal NK/T-cell Lymphoma, Nasal Type Accompanied by PR3-ANCA-associated Glomerulonephritis

被引：4

作者：

Tamoto, Yuta ^{[1
]}

Ishida, Ryo ^{[1
]}

Shiogama, Kazuya ^{[2
]}

Kado, Hiroshi ^{[1
]}

Kamezaki, Michitsugu ^{[1
]}

Chinen, Yoshiaki ^{[3
]}

Matsumoto, Yosuke ^{[4
,5
]}

Kusaba, Tetsuro ^{[1
]}

Konishi, Eiichi ^{[6
]}

Tsutsumi, Yutaka ^{[2
]}

Tamagaki, Keiichi ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Div Nephrol, Dept Med, Kyoto, Japan

[2] Fujita Hlth Univ, Sch Med, Dept Pathol, Toyoake, Aichi, Japan

[3] Kyoto Prefectural Univ Med, Div Hematol & Oncol, Dept Med, Kyoto, Japan

[4] Aiseikai Yamashina Hosp, Dept Hematol, Kyoto, Japan

[5] Aiseikai Yamashina Hosp, Dept Lab Med, Kyoto, Japan

[6] Kyoto Prefectural Univ Med, Dept Surg Pathol, Kyoto, Japan

来源：

INTERNAL MEDICINE | 2017年 / 56卷 / 15期

关键词：

extranodal NK/T-cell lymphoma; nasal type; proteinase 3 antineutrophil cytoplasmic antibodies; neutrophil; apoptosis; ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; ANCA-ASSOCIATED VASCULITIS; LYMPHOPROLIFERATIVE DISORDERS; MYELODYSPLASTIC SYNDROMES; SYSTEMIC VASCULITIS; GRANULOMATOSIS; ASSOCIATION; NEUTROPHILS; MANAGEMENT; APOPTOSIS;

D O I：

10.2169/internalmedicine.56.8365

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 62-year-old man exhibiting nasal obstruction and glomerulonephritis with proteinase 3-antineutrophil cytoplasmic antibodies (PR3-ANCAs) was diagnosed with extranodal NK/T-cell lymphoma, nasal type (ENKL) with infiltration of neutrophils with apoptosis. Chemoradiotherapy reduced the tumor, improved the renal function, and decreased the PR3-ANCA levels. ANCA-positivity is observed in immunoinsufficient diseases, in which neutrophils lead to apoptosis and translocate intracellular granules, such as PR3, to the cell surface, triggering the production of ANCAs. In our case, the PR3-ANCA production was derived from the expression of PR3 on the cell surface of apoptotic neutrophils. This is the first report on ENKL describing the mechanism of ANCA development.

引用

页码：2007 / 2012

页数：6

共 45 条

[1] Extranodal NK/T-cell Lymphoma, Nasal Type, Arising in Association With Saline Breast Implant Expanding the Spectrum of Breast Implant-associated Lymphomas [J].

Aladily, Tariq N. ;

Nathwani, Bharat N. ;

Miranda, Roberto N. ;

Kansal, Rina ;

Yin, C. Cameron ;

Protzel, Richard ;

Takowsky, Gary S. ;

Medeiros, L. Jeffrey .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2012, 36 (11) :1729-1734

[2] ENVIRONMENTAL TRIGGER FOR ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES [J].

BARRETT, TG ;

TAYLOR, CM ;

THOMASON, P ;

PALL, A ;

ADU, D .

LANCET, 1993, 342 (8867) :369-370

[3]

Bhatt VR, 2011, BMJ CASE REP

[4]

BILLSTROM R, 1995, EUR J HAEMATOL, V55, P42

[5] Neutrophil extracellular traps kill bacteria [J].

Brinkmann, V ;

Reichard, U ;

Goosmann, C ;

Fauler, B ;

Uhlemann, Y ;

Weiss, DS ;

Weinrauch, Y ;

Zychlinsky, A .

SCIENCE, 2004, 303 (5663) :1532-1535

[6] alpha(1)-antitrypsin (AAT) deficiency and ANCA-positive systemic vasculitis: genetic and clinical implications [J].

Callea, F ;

Gregorini, G ;

Sinico, A ;

Gonzales, G ;

Bossolasco, M ;

Salvidio, G ;

Radice, A ;

Tira, P ;

Candiano, G ;

Rossi, G ;

Petti, A ;

Ravera, G ;

Ghiggeri, G ;

Gusmano, R .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1997, 27 (08) :696-702

[7] Extranodal lymphomas of head and neck with emphasis on NK/T-cell lymphoma, nasal type [J].

Coha, Bozena ;

Vucinic, Ivana ;

Mahovne, Ivana ;

Vukovic-Arar, Zeljka .

JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 2014, 42 (02) :149-152

[8] VASCULITIS AND ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES ASSOCIATED WITH PROPYLTHIOURACIL THERAPY [J].

DOLMAN, KM ;

GANS, ROB ;

VERVAAT, TJ ;

ZEVENBERGEN, G ;

MAINGAY, D ;

NIKKELS, RE ;

DONKER, AJM ;

BORNE, AEGKV ;

GOLDSCHMEDING, R .

LANCET, 1993, 342 (8872) :651-652

[9] Autoimmune phenomena in patients with myelodysplastic syndromes [J].

Enright, H ;

Miller, W .

LEUKEMIA & LYMPHOMA, 1997, 24 (5-6) :483-489

[10] Extranodal natural killer/T-cell lymphoma, nasal type, with prominent granulomatous reaction [J].

Fujimoto, Noriki ;

Takahashi, Toshifumi ;

Yamashita, Mami ;

Nakanishi, Gen ;

Okabe, Hidetoshi ;

Tanaka, Toshihiro .

JOURNAL OF DERMATOLOGY, 2014, 41 (01) :68-69

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