GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan

被引:17
作者
Gilfarb, Rachel A. [1 ]
Leuner, Benedetta [2 ,3 ]
机构
[1] Ohio State Univ, Neurosci Grad Program, Columbus, OH USA
[2] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA
[3] Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA
来源
FRONTIERS IN BEHAVIORAL NEUROSCIENCE | 2022年 / 16卷
关键词
GABA; estradiol; progesterone; puberty; ovarian cycle; pregnancy; postpartum; menopause; ESTROGEN-RECEPTOR-BETA; DORSOLATERAL PREFRONTAL CORTEX; GONADOTROPIN-RELEASING-HORMONE; SERUM ALLOPREGNANOLONE LEVELS; AMINOBUTYRIC-ACID LEVELS; MENSTRUAL-CYCLE; POSTPARTUM DEPRESSION; CEREBROSPINAL-FLUID; GENE-EXPRESSION; ORAL-CONTRACEPTIVES;
D O I
10.3389/fnbeh.2022.802530
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The female lifespan is marked by periods of dramatic hormonal fluctuation. Changes in the ovarian hormones estradiol and progesterone, in addition to the progesterone metabolite allopregnanolone, are among the most significant and have been shown to have widespread effects on the brain. This review summarizes current understanding of alterations that occur within the GABA system during the major hormonal transition periods of puberty, the ovarian cycle, pregnancy and the postpartum period, as well as reproductive aging. The functional impacts of altered inhibitory activity during these times are also discussed. Lastly, avenues for future research are identified, which, if pursued, can broaden understanding of the GABA system in the female brain and potentially lead to better treatments for women experiencing changes in brain function at each of these hormonal transition periods.
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收藏
页数:17
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