Therapeutic Targeting of the Colorectal Tumor Stroma

被引：60

作者：

Fridman, Wolf H. ^{[1
]}

Miller, Ian S. ^{[2
]}

Sautes-Fridman, Catherine ^{[1
]}

Byrne, Annette T. ^{[2
]}

机构：

[1] Univ Paris, Sorbonne Univ, Ctr Rech Cordeliers, INSERM,Inflammat Complement & Canc Team, Paris, France

[2] Royal Coll Surgeons Ireland, Dept Physiol & Med Phys, Dublin, Ireland

来源：

GASTROENTEROLOGY | 2020年 / 158卷 / 02期

基金：

爱尔兰科学基金会;

关键词：

CRC; MSI; Matrix; Microenvironment; ENDOTHELIAL GROWTH-FACTOR; CONSENSUS MOLECULAR SUBTYPES; FOLFIRI PLUS BEVACIZUMAB; COLON-CANCER; 1ST-LINE TREATMENT; IMMUNE CONTEXTURE; TGF-BETA; T-CELLS; MICROVESSEL DENSITY; RANDOMIZED-TRIAL;

D O I：

10.1053/j.gastro.2019.09.045

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Colorectal tumors have been classified based on histologic factors, genetic factors, and consensus molecular subtypes, all of which affect the tumor microenvironment. Elements of the tumor microenvironment serve as therapeutic targets and might be used as prognostic factors. For example, immune checkpoint inhibitors are used to treat tumors with microsatellite instability, and anti-angiogenic agents may be used in combination with other drugs to slow or inhibit tumor growth. We review the features of the colorectal tumor stroma that are associated with patient outcomes and discuss potential therapeutic agents that target these features.

引用

页码：303 / 321

页数：19

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