Palladium-catalyzed tandem alkenyl and aryl C-N bond formation: A cascade N-annulation route to 1-functionalized indoles

被引：167

作者：

Willis, MC ^{[1
]}

Brace, GN

Holmes, IP

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[2] GlaxoSmithKline, Discovery Res, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 03期

关键词：

amination; cascade reactions; indoles; nitrogen heterocycles; palladium;

D O I：

10.1002/anie.200461598

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A single tandem operation allows rapid access to a variety of substituted N-functionalized indoles. The nitrogen atom of the indole nucleus is incorporated through Pd-catalyzed aryl and alkenyl C-N bond-forming reactions (see scheme; dba = dibenzylideneacetone). Amine, aniline, amide, carbamate, and sulfonamide functional groups can be introduced efficiently.

引用

页码：403 / 406

页数：4

共 34 条

[1] Serotonin 5-HT2 receptor, dopamine D-2 receptor, and alpha(1) adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole [J].