Emerging roles for E2F: Beyond the G1/S transition and DNA replication

被引：281
作者：
Cam, H [1 ]
Dynlacht, BD [1 ]
机构：
[1] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA
来源：
CANCER CELL | 2003年 / 3卷 / 04期
关键词：
D O I：
10.1016/S1535-6108(03)00080-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
E2F activity is crucial for the G1/S transition and DNA replication in mammalian cells. The retinoblastoma (pRB) family of proteins is the primary negative regulator of E2F. Recent findings have begun to clarify distinct roles for E2F family members during cell cycle progression and have considerably broadened our understanding of E2F transcriptional control beyond S phase. In this review, we examine the relative contribution of two distinct subclasses of E2F to repression and activation and how this division of labor could explain the role of E2F in DNA damage and repair checkpoints as well as tumorigenesis.
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页码：311 / 316
页数：6
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