Differently Selected D-Enantiomeric Peptides Act on Different Aβ Species

被引：21

作者：

Bartnik, Dirk ^{[2
]}

Funke, Susanne Aileen ^{[1
]}

Andrei-Selmer, Luminita-Cornelia ^{[3
]}

Bacher, Michael ^{[3
]}

Dodel, Richard ^{[3
]}

Willbold, Dieter ^{[1
,2
]}

机构：

[1] Forschungszentrum Julich, ISB 3, D-52425 Julich, Germany

[2] Univ Dusseldorf, Inst Phys Biol, D-40225 Dusseldorf, Germany

[3] Univ Marburg, Dept Neurol, Biomed Forschungszentrum, D-35037 Marburg, Germany

来源：

REJUVENATION RESEARCH | 2010年 / 13卷 / 2-3期

关键词：

IMAGE PHAGE DISPLAY; ALZHEIMERS-DISEASE; SYNAPTIC PLASTICITY; PROTEIN OLIGOMERS;

D O I：

10.1089/rej.2009.0924

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aging is the most significant risk factor for Alzheimer disease (AD). The pathological hallmark of AD is the accumulation of aggregated amyloid-beta (A beta) forms and insoluble plaques, mainly composed of A beta, in the brain of the patient. Recently, we reported on the selection of D-enantiomeric, A beta-binding peptides D1 and D3. D1 was selected against aggregated A beta species to address diagnosis by in vivo imaging of amyloid plaques, whereas D3 was selected using low-molecular-weight A beta species, therefore addressing therapeutical studies. Here, we use a surface plasmon resonance method to confirm that both peptides show the desired binding specificities.

引用

页码：202 / 205

页数：4

共 14 条

[1] Forecasting the global burden of Alzheimer's disease [J].

Brookmeyer, Ron ;

Johnson, Elizabeth ;

Ziegler-Graham, Kathryn ;

Arrighi, H. Michael .

ALZHEIMERS & DEMENTIA, 2007, 3 (03) :186-191

[2] Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide [J].

Haass, Christian ;

Selkoe, Dennis J. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (02) :101-112

[3] ALZHEIMERS-DISEASE - THE AMYLOID CASCADE HYPOTHESIS [J].

HARDY, JA ;

HIGGINS, GA .

SCIENCE, 1992, 256 (5054) :184-185

[4] Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers [J].

Lauren, Juha ;

Gimbel, David A. ;

Nygaard, Haakon B. ;

Gilbert, John W. ;

Strittmatter, Stephen M. .

NATURE, 2009, 457 (7233) :1128-U84

[5] Therapeutic peptides [J].

Lien, S ;

Lowman, HB .

TRENDS IN BIOTECHNOLOGY, 2003, 21 (12) :556-562

[6]

Markey F., 1999, BIA J, V6, P14

[7]

Shankar GM, 2008, NAT MED, V14, P837, DOI 10.1038/nm1782

[8] Reduction of Alzheimer's Disease Amyloid Plaque Load in Transgenic Mice by D3, a D-Enantiomeric Peptide Identified by Mirror Image Phage Display [J].

van Groen, Thomas ;

Wiesehann, Katia ;

Funke, Susanne A. ;

Kadish, Inga ;

Nagel-Steger, Luitgard ;

Willbold, Dieter .

CHEMMEDCHEM, 2008, 3 (12) :1848-1852

[9] In vitro and in vivo Staining Characteristics of Small, Fluorescent, Aβ42-Binding D-Enantiomeric Peptides in Transgenic AD Mouse Models [J].

van Groen, Thomas ;

Kadish, Inga ;

Wiesehan, Katja ;

Funke, Susanne A. ;

Willbold, Dieter .

CHEMMEDCHEM, 2009, 4 (02) :276-282

[10] D-peptides as immunogens and diagnostic reagents [J].

Van Regenmortel, MHV ;

Muller, S .

CURRENT OPINION IN BIOTECHNOLOGY, 1998, 9 (04) :377-382

← 1 2 →