Inhibiting virus-capsid assembly by altering the polymerisation pathway

被引：59

作者：

Prevelige, PE ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

来源：

TRENDS IN BIOTECHNOLOGY | 1998年 / 16卷 / 02期

关键词：

D O I：

10.1016/S0167-7799(97)01154-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Virus capsids assemble through the repeated interaction of well-defined protein subunits in a highly specific process. Basic research into the mechanism of protein polymerisation and virus assembly suggest that inhibition of the protein-protein interactions necessary for assembly is a valid therapeutic strategy. Computer models of virus-capsid assembly have located vulnerable stages in assembly, and small-molecule inhibitors of virus assembly have been identified. The challenge will be identifying agents that block assembly with the required specificity.

引用

页码：61 / 65

页数：5

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