Circulating oestrogen receptor mutations and splice variants in advanced prostate cancer

被引：12

作者：

Qu, Liang G. ^{[1
]}

Wardan, Hady ^{[1
]}

Davis, Ian D. ^{[1
,2
]}

Iddawela, Mahesh ^{[3
]}

Sluka, Pavel ^{[1
]}

Pezaro, Carmel J. ^{[1
,2
,3
]}

机构：

[1] Monash Univ, Eastern Hlth Clin Sch, Level 4,8 Arnold St, Box Hill, Vic 3128, Australia

[2] Eastern Hlth, Dept Oncol, Box Hill, Vic, Australia

[3] Monash Univ, Prostate Canc Res Grp, Biomed Discovery Inst, Melbourne, Vic, Australia

来源：

BJU INTERNATIONAL | 2019年 / 124卷

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

advanced prostate cancer; tumour biomarkers; circulating nucleic acids; oestrogen receptors; hormone receptors; ESR1; MUTATIONS; TUMOR-CELLS; DIETHYLSTILBESTROL; ABIRATERONE; ENZALUTAMIDE; MANAGEMENT; RESISTANCE; DESIGN; TRIAL; BETA;

D O I：

10.1111/bju.14797

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Objective To characterize circulating oestrogen receptor ( ER) mutants and splice variants in men with advanced prostate cancer. Materials and Methods Sequential blood samples were obtained from men with advanced prostate cancer, and from healthy controls. Blood-derived RNA samples were analysed using droplet digital PCR for the presence of six ER alpha mutations (E380Q, L536Q, Y537C, Y537S, Y537N and D538G), and six ER alpha and ER beta splice variants (ER alpha-66, ER alpha-36, ER beta 1, ER beta 2, ER beta 4 & ER beta 5). Results A total of 94 samples were collected from 42 men with advanced prostate cancer. Four mutations (E380Q, L536Q, Y537S and D538G) and all six splice variants were detected in patient samples. Splice variants were detectable in non-cancer control samples. The presence of ER mutations was associated with bone metastases and castration resistance. ER beta splice variant concentrations decreased after successive lines of treatment. Conclusions The ER mutations were detectable in plasma from patients with advanced prostate cancer. ER splice variants were frequently detected in both men with and without prostate cancer.

引用

页码：50 / 56

页数：7

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