Expression of TGF-βs and TGF-β type II receptor in cerebrospinal fluid of patients with idiopathic normal pressure hydrocephalus

被引：50

作者：

Li, Xianfeng

Miyajima, Masakazu

Jiang, Chuanlu ^{[1
]}

Arai, Hajime

机构：

[1] Juntendo Univ, Sch Med, Dept Neurosurg, Tokyo 113, Japan

[2] Harbin Med Coll, Affiliated Hosp 2, Dept Neurosurg, Heilongjiang 150086, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2007年 / 413卷 / 02期

关键词：

cerebrospinal fluid; ELISA; idiopathic normal pressure hydrocephalus; TGF-beta;

D O I：

10.1016/j.neulet.2006.11.039

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated cerebrospinal fluid (CSF) samples from 21 patients with idiopathic normal pressure hydrocephalus (INPH) and 14 controls without neurological disease. The concentrations of leucine-rich alpha-2-alycoprotein (LRG), transforming growth factor (TGF)-beta 1, 2, 3 and TGF-beta type II receptor (T beta R-II) in CSF were measured using ELISA. TGF-beta I, T beta R-II and LRG CSF levels of patients with INPH were significantly higher than controls, whereas no significant differences in TGF-beta 2 levels were found between INPH patients and controls. The present study suggests that TGF-beta s expressions may be modulated differently in patients with INPH. These results also indicate that the CSF level assay of TGF-beta 1. T beta R-II and LRG is useful for the diagnosis of patients with INPH, and TGF-beta 1, T beta R-II and LRG may be involved in the pathogenesis of the disease. (c) 2006 Published by Elsevier Ireland Ltd.

引用

页码：141 / 144

页数：4

共 21 条

[11] ELEVATION OF TRANSFORMING GROWTH-FACTOR-BETA-1 LEVEL IN CEREBROSPINAL-FLUID OF PATIENTS WITH COMMUNICATING HYDROCEPHALUS AFTER SUBARACHNOID HEMORRHAGE [J].