Extracorporeal support for patients with acute and acute on chronic liver failure

被引：14

作者：

Aron, Jonathan ^{[1
]}

Agarwal, Banwari ^{[2
]}

Davenport, Andrew ^{[3
]}

机构：

[1] Kings Coll Hosp London, London, England

[2] Royal Free Hosp, Intens Care Unit, Pond St, London NW3 2QG, England

[3] Royal Free Hosp, UCL Ctr Nephrol, Pond St, London NW3 2QG, England

来源：

EXPERT REVIEW OF MEDICAL DEVICES | 2016年 / 13卷 / 04期

关键词：

biological and plasma filtration; plasma exchange; adsorption; Acute liver failure; acute on chronic liver failure; ADSORBENT RECIRCULATING SYSTEM; FRACTIONATED PLASMA SEPARATION; RENAL REPLACEMENT THERAPY; ALBUMIN-BINDING CAPACITY; BIOARTIFICIAL LIVER; CONTROLLED-TRIAL; HEPATIC-ENCEPHALOPATHY; INTRACRANIAL-PRESSURE; HEPATORENAL-SYNDROME; ASSIST DEVICE;

D O I：

10.1586/17434440.2016.1154455

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The number of patients developing liver failure; acute on chronic liver failure and acute liver failure continues to increase, along with the demand for donor livers for transplantation. As such there is a clinical need to develop effective extracorporeal devices to support patients with acute liver failure or acute-on-chronic liver failure to allow time for hepatocyte regeneration, and so avoiding the need for liver transplantation, or to bridge the patient to liver transplantation, and also potentially to provide symptomatic relief for patients with cirrhosis not suitable for transplantation. Currently devices can be divided into those designed to remove toxins, including plasma exchange, high permeability dialyzers and adsorption columns or membranes, coupled with replacement of plasma proteins; albumin dialysis systems; and bioartificial devices which may provide some of the biological functions of the liver. In the future we expect combinations of these devices in clinical practice, due to the developments in bioartificial scaffolds.

引用

页码：367 / 380

页数：14

共 73 条

[1] Renal dysfunction in cirrhosis is not just a vasomotor nephropathy [J].