FOXP3 modifies the phenotypic and functional properties of regulatory T cells

被引:207
作者
Campbell, Daniel J.
Ziegler, Steven F. [1 ]
机构
[1] Benaroya Res Inst Virginia Mason, Program Immunol, Seattle, WA 98101 USA
[2] Univ Washington, Sch Med, Dept Immunol, Seattle, WA 98195 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nri2061
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In the periphery, tolerance to self antigens is mainly mediated by the CD4(+)CD25(+)FOXP3(+) subset of regulatory T cells, which can suppress the activity of autoreactive T cells that have escaped deletion in the thymus. The essential role of the transcription factor FOXP3 (forkhead box P3) in the development and function of these regulatory T cells has been well documented. It is also clear that regulatory T cells and effector T cells respond differently to T-cell receptor stimulation. In this Opinion article, we propose that these differences in responses are mediated by FOXP3, and are manifested by alterations in biochemical signalling pathways, patterns of gene expression and the appearance of cell-surface homing receptors.
引用
收藏
页码:305 / 310
页数:6
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