Enediynes: Exploration of microbial genomics to discover new anticancer drug leads

被引：53
作者：
Shen, Ben [1 ,2 ,3 ]
Hindra [1 ]
Yan, Xiaohui [1 ]
Huang, Tingting [1 ]
Ge, Huiming [1 ]
Yang, Dong [1 ]
Teng, Qihui [1 ]
Rudolf, Jeffrey D. [1 ]
Lohman, Jeremy R. [1 ]
机构：
[1] Scripps Res Inst, Dept Chem, Jupiter, FL 33458 USA
[2] Scripps Res Inst, Dept Mol Therapeut, Jupiter, FL 33458 USA
[3] Scripps Res Inst, Nat Prod Lib Initiat, Jupiter, FL 33458 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Enediyne polyketide synthase; Biosynthetic gene cluster; Genome mining; ADC payload; Natural products; BIOSYNTHETIC GENE-CLUSTER; NATURAL-PRODUCTS; ANTITUMOR ANTIBIOTICS; RADIOMIMETIC ENEDIYNE; CROSS-LINKS; CHROMOPHORE; CHEMISTRY; C-1027; FAMILY; CORE;
D O I：
10.1016/j.bmcl.2014.11.019
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The enediyne natural products have been explored for their phenomenal cytotoxicity. The development of enediynes into anticancer drugs has been successfully achieved through the utilization of polymer-and antibody-drug conjugates (ADCs) as drug delivery systems. An increasing inventory of enediynes would benefit current application of ADCs in many oncology programs. Innovations in expanding the enediyne inventory should take advantage of the current knowledge of enediyne biosynthesis and post-genomics technologies. Bioinformatics analysis of microbial genomes reveals that enediynes are underexplored, in particular from Actinomycetales. This digest highlights the emerging opportunities to explore microbial genomics for the discovery of novel enediyne natural products. (C) 2014 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license
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收藏
页码：9 / 15
页数：7
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