Radical induced fragmentation of amino acid esters using triphenylcorrole(CuIII) complexes

被引：7

作者：

Denekamp, Chagit ^{[1
]}

Rabkin, Emilia

机构：

[1] Technion Israel Inst Technol, Dept Chem, IL-32000 Haifa, Israel

[2] Technion Israel Inst Technol, Inst Catalysis Sci & Technol, IL-32000 Haifa, Israel

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2007年 / 18卷 / 04期

关键词：

ELECTRON-CAPTURE DISSOCIATION; TANDEM MASS-SPECTROMETRY; STRUCTURAL-CHARACTERIZATION; REDOX REACTIONS; PEPTIDE; DISTINCTION; ISOLEUCINE; LEUCINE; CATIONS; PROTEIN;

D O I：

10.1016/j.jasms.2006.12.010

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A triphenylcorrole(CuIII) complex is covalently bound to amino acid esters at the nitrogen atom. As a result radical anions are generated, inducing the occurrence of side-chain reactions under CID conditions. Almost all of the amino acid esters that were studied show abundant ions that correspond to fragmentation at the alpha carbon either with or without the loss of the alkoxy ester moiety. Distinctive CID spectra were also recorded for leucine and isoleucine complexes. Initial results with short peptides are also shown.

引用

页码：791 / 801

页数：11

共 52 条

[1]

Ayorinde FO, 1999, RAPID COMMUN MASS SP, V13, P2474, DOI 10.1002/(SICI)1097-0231(19991230)13:24<2474::AID-RCM814>3.0.CO

[2]

2-0

[3] Copper-mediated peptide radical ions in the gas phase [J].

Bagheri-Majdi, E ;

Ke, YY ;

Orlova, G ;

Chu, IK ;

Hopkinson, AC ;

Siu, KWM .

JOURNAL OF PHYSICAL CHEMISTRY B, 2004, 108 (30) :11170-11181

[4] Formation of cationic peptide radicals by gas-phase redox reactions with trivalent chromium, manganese, iron, and cobalt complexes [J].

Barlow, CK ;

McFadyen, WD ;

O'Hair, RAJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (16) :6109-6115

[5] Designing copper(II) ternary complexes to generate radical cations of peptides in the gas phase: Role of the auxiliary ligand [J].

Barlow, CK ;

Wee, S ;

McFadyen, WD ;

O'Hair, RAJ .

DALTON TRANSACTIONS, 2004, (20) :3199-3204

[6] Proteomics by FTICR mass spectrometry: Top down and bottom up [J].

Bogdanov, B ;

Smith, RD .

MASS SPECTROMETRY REVIEWS, 2005, 24 (02) :168-200

[7] Electrospray mass spectrometric study of anionic complexes of enkephalins with Cu(II):: regioselective distinction of Leu/Ile at the C-terminus induced by metal reduction [J].

Bossée, A ;

Fournier, F ;

Tasseau, O ;

Bellier, B ;

Tabet, JC .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2003, 17 (12) :1229-1239

[8] Formation of molecular radical cations of aliphatic tripeptides from their complexes with CuII(12-crown-4) [J].

Chu, IK ;

Siu, SO ;

Lam, CNW ;

Chan, JCY ;

Rodriquez, CF .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2004, 18 (16) :1798-1802

[9] Molecular radical cations of oligopeptides [J].

Chu, IK ;

Rodriquez, CF ;

Lau, TC ;

Hopkinson, AC ;

Siu, KWM .

JOURNAL OF PHYSICAL CHEMISTRY B, 2000, 104 (15) :3393-3397

[10] Characterization of amino acid side chain losses in electron capture dissociation [J].

Cooper, HJ ;

Hudgins, RR ;

Håkansson, K ;

Marshall, AG .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2002, 13 (03) :241-249

← 1 2 3 4 5 6 →