Epidemiological and clinical characteristics of patients infected with enterovirus D68, France, July to December 2014

被引：37

作者：

Schuffenecker, I. ^{[1
,2
]}

Mirand, A. ^{[3
,4
]}

Josset, L. ^{[1
,2
]}

Henquell, C. ^{[3
,4
]}

Hecquet, D. ^{[5
]}

Pilorge, L. ^{[6
]}

Petitjean-Lecherbonnier, J. ^{[7
]}

Manoha, C. ^{[8
]}

Legoff, J. ^{[9
]}

Deback, C. ^{[10
]}

Pillet, S. ^{[11
]}

Lepiller, Q. ^{[12
]}

Mansuy, J. M. ^{[13
]}

Marque-Juillet, S. ^{[14
]}

Antona, D. ^{[15
]}

Peigue-Lafeuille, H. ^{[3
,4
]}

Lina, B. ^{[1
,2
]}

机构：

[1] Hosp Civils Lyon, Virol Lab, Ctr Natl Reference Enterovirus & Parechovirus, Lyon, France

[2] Univ Lyon 1, Lab Virpath, EA4610, Fac Med Lyon Est, F-69365 Lyon, France

[3] CHU Clermont Ferrand, Virol Lab, Ctr Natl Reference Enterovirus & Parechovirus, Lab Assoc, Clermont Ferrand, France

[4] Univ Auvergne, Epidemiol & Pathogenie Infect Enterovirus EA4843, Clermont Ferrand, France

[5] CHU Amiens, Virol Lab, Amiens, France

[6] CHRU Cavale Blanche, Virol Lab, Brest, France

[7] CHU Caen, Virol Lab, F-14000 Caen, France

[8] CHU Dijon, Virol Lab, Dijon, France

[9] Hop St Louis, AP HP, Microbiol Lab, Paris, France

[10] Hop Paul Brousse, AP HP, Virol Lab, Villejuif, France

[11] CHU St Etienne, Lab Agents Infect & Hyg, St Etienne, France

[12] Hop Univ Strasbourg, Virol Lab, Strasbourg, France

[13] CHU Toulouse, Virol Lab, Toulouse, France

[14] CH Versailles, Microbiol Lab, Versailles, France

[15] Inst Veille Sanit, Dept Malad Infect, St Maurice, France

来源：

EUROSURVEILLANCE | 2016年 / 21卷 / 19期

关键词：

ACUTE RESPIRATORY-INFECTIONS; PEDIATRIC-PATIENTS; EMERGENCE; OUTBREAK; CHILDREN; IDENTIFICATION; SURVEILLANCE; REEMERGENCE; STRAINS; ILLNESS;

D O I：

10.2807/1560-7917.ES.2016.21.19.30226

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In 2014, the United States (US) experienced a nationwide outbreak of enterovirus D68 (EV-D68) infection with 1,152 cases reported mainly in hospitalised children with severe asthma or bronchiolitis. Following the US alert, 11 laboratories of the French enterovirus (EV) surveillance network participated in an EV-D68 survey. A total of 6,229 respiratory samples, collected from 1 July to 31 December 2014, were screened for EV-D68 resulting in 212 EV-D68-positive samples. These 212 samples corresponded to 200 EV-D68 cases. The overall EV-D68 positivity rates among respiratory samples were of 5% (184/3,645) and 1.1% (28/2,584) in hospitalised children and adults respectively. The maximum weekly EV-D68 positivity rates were of 16.1% for children (n = 24/149; week 43) and 2.6% for adults (n = 3/115; week 42). Of 173 children with EV-D68 infection alone, the main symptoms were asthma (n = 83; 48.0%) and bronchiolitis (n = 37; 21.4%). One child developed acute flaccid paralysis (AFP) following EV-D68-associated pneumonia. Although there was no significant increase in severe respiratory tract infections reported to the French public health authorities, 10.7% (19/177) of the EV-D68 infected children and 14.3% (3/21) of the EV-D68 infected adults were hospitalised in intensive care units. Phylogenetic analysis of the viral protein 1 (VP1) sequences of 179 EV-D68 cases, revealed that 117 sequences (65.4%), including that of the case of AFP, belonged to the B2 variant of clade B viruses. Continuous surveillance of EV-D68 infections is warranted and could benefit from existing influenza-like illness and EV surveillance networks. © 2016, European Centre for Disease Prevention and Control (ECDC). All rights reserved.

引用

页码：4 / 15

页数：12

共 38 条

[31] The emergence of enterovirus D68 in a Dutch University Medical Center and the necessity for routinely screening for respiratory viruses [J].