Synthesis of dihydrooxazole analogues derived from linezolid

被引：8

作者：

Einsiedel, J

Schoerner, C

Gmeiner, P

机构：

[1] Univ Erlangen Nurnberg, Emil Fischer Ctr, Dept Med Chem, D-91052 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Inst Clin Microbiol Immunol & Hyg, D-91054 Erlangen, Germany

来源：

TETRAHEDRON | 2003年 / 59卷 / 19期

关键词：

serine; dihydrooxazoles; antibiotics;

D O I：

10.1016/S0040-4020(03)00490-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from (S)-serine, the linezolid analogue 3 with dihydrooxazole partial structure was synthesized and pharmacologically investigated. With the help of MEP comparisons structural requirements for antibacterial activity were evaluated. (C) 2003 Elsevier Science Ltd. All rights reserved.

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收藏

页码：3403 / 3407

页数：5

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