The impact of drugs on male fertility: a review

被引：186

作者：

Semet, M. ^{[1
]}

Paci, M. ^{[1
,2
]}

Saias-Magnan, J. ^{[1
]}

Metzler-Guillemain, C. ^{[1
,2
]}

Boissier, R. ^{[3
,4
]}

Lejeune, H. ^{[5
]}

Perrin, J. ^{[1
,6
]}

机构：

[1] AP HM La Conception, Pole Femmes Parents Enfants, Ctr Clin Biol Assistance Med Procreat CECOS, 147 Bd Baille, F-13005 Marseille, France

[2] Aix Marseille Univ, INSERM, GMGF UMR S 910, Marseille, France

[3] Aix Marseille Univ, Marseille, France

[4] Conception Univ Hosp, AP HM, Dept Urol & Renal Transplantat, Marseille, France

[5] CHU Lyon, Hop Femme Mere Enfant, Serv Med Reprod, Bron, France

[6] Aix Marseille Univ, Univ Avignon, CNRS, IRD,IMBE, Marseille, France

来源：

ANDROLOGY | 2017年 / 5卷 / 04期

关键词：

ejaculation disorder; impotence; male infertility; medication; medicine; semen parameters; toxicity for reproduction; BENIGN PROSTATIC HYPERPLASIA; INFLAMMATORY-BOWEL-DISEASE; MALE HYPERCHOLESTEROLEMIC PATIENTS; REPRODUCTIVE ENDOCRINE FUNCTION; ANDROGEN DEPRIVATION THERAPY; INDUCED SEXUAL DYSFUNCTION; RANDOMIZED DOUBLE-BLIND; GERM-CELL APOPTOSIS; CHRONIC HEPATITIS-C; HIV-INFECTED MEN;

D O I：

10.1111/andr.12366

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

Beside cytotoxic drugs, other drugs can impact men's fertility through various mechanisms. Via the modification of the hypothalamic-pituitary-gonadal axis hormones or by non-hormonal mechanisms, drugs may directly and indirectly induce sexual dysfunction and spermatogenesis impairment and alteration of epididymal maturation. This systematic literature review summarizes existing data about the negative impact and associations of pharmacological treatments on male fertility (excluding cytotoxic drugs), with a view to making these data more readily available for medical staff. In most cases, these effects on spermatogenesis/sperm maturation/sexual function are reversible after the discontinuation of the drug. When a reprotoxic treatment cannot be stopped and/or when the impact on semen parameters/sperm DNA is potentially irreversible (Sulfasalazine Azathioprine, Mycophenolate mofetil and Methotrexate), the cryopreservation of spermatozoa before treatment must be proposed. Deleterious impacts on fertility of drugs with very good or good level of evidence (Testosterone, Sulfasalazine, Anabolic steroids, Cyproterone acetate, Opioids, Tramadol, GhRH analogues and Sartan) are developed.

引用

页码：640 / 663

页数：24

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