Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition?

被引：20
|
作者：
Collier, Mary E. W. [1 ]
Zhang, Shaowei [2 ]
Scrutton, Nigel S. [2 ]
Giorgini, Flaviano [1 ]
机构：
[1] Univ Leicester, Dept Genet & Genome Biol, Leicester LE1 7RH, Leics, England
[2] Univ Manchester, Manchester Inst Biotechnol, Dept Chem, Sch Nat Sci, 131 Princess St, Manchester M1 7DN, Lancs, England
来源：
DRUG DISCOVERY TODAY | 2021年 / 26卷 / 06期
基金：
英国工程与自然科学研究理事会;
关键词：
ARYL-HYDROCARBON RECEPTOR; T-CELL PROLIFERATION; INDOLEAMINE 2,3-DIOXYGENASE; QUINOLINIC ACID; CEREBROSPINAL-FLUID; PATHWAY INHIBITION; FRONTAL-CORTEX; METABOLISM; BRAIN; MODULATION;
D O I：
10.1016/j.drudis.2021.02.009
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The novel respiratory virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), emerged during late 2019 and spread rapidly across the world. It is now recognised that the nervous system can be affected in COVID-19, with several studies reporting long-term cognitive problems in patients. The metabolic pathway of tryptophan degradation, known as the kynurenine pathway (KP), is significantly activated in patients with COVID-19. KP metabolites have roles in regulating both inflammatory/immune responses and neurological functions. In this review, we speculate on the effects of KP activation in patients with COVID-19, and how modulation of this pathway might impact inflammation and reduce neurological symptoms.
引用
收藏
页码：1473 / 1481
页数：9
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