Generating Nonlinear Models of Functional Connectivity from Functional Magnetic Resonance Imaging Data with Genetic Programming

被引:0
作者
Hughes, James Alexander [1 ]
Daley, Mark [2 ]
机构
[1] St Francis Xavier Univ, Math Stat & Comp Sci, Antigonish, NS, Canada
[2] Univ Western Ontario, Dept Comp Sci, London, ON, Canada
来源
2019 IEEE CONGRESS ON EVOLUTIONARY COMPUTATION (CEC) | 2019年
基金
加拿大自然科学与工程研究理事会;
关键词
Computational Neuroscience; Functional Connectivity; Functional Magnetic Resonance Imaging; Genetic Programming; Symbolic Regression; DEGENERACY; RESPONSES; FMRI;
D O I
10.1109/cec.2019.8790120
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
The brain is a nonlinear computational system; however, most methods employed in finding functional connectivity models with functional magnetic resonance imaging (fMRI) data produce strictly linear models - models incapable of truly describing the underlying system. Genetic programming is used to develop nonlinear models of functional connectivity from fMRI data. The study builds on previous work and observes that nonlinear models contain relationships not found by traditional linear methods. When compared to linear models, the nonlinear models contained fewer regions of interest and were never significantly worse when applied to data the models were fit to. Nonlinear models could generalize to unseen data from the same subject better than traditional linear models (intrasubject). Nonlinear models could not generalize to unseen data recorded from other subjects (intersubject) as well as the linear models, and reasons for this are discussed. This study presents the problem that many, manifestly different models in both operators and features, can effectively describe the system with acceptable metrics.
引用
收藏
页码:3252 / 3261
页数:10
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