Cost-effectiveness analysis of endoscopic eradication therapy for treatment of high-grade dysplasia in Barrett's esophagus

被引：5
作者：
Filby, Alex [1 ]
Taylor, Matthew [1 ]
Lipman, Gideon [2 ]
Lovat, Laurence [2 ,3 ]
Haidry, Rehan [2 ,3 ]
机构：
[1] Univ York, YHEC, Enterprise House,Innovat Way, York, N Yorkshire, England
[2] Univ Coll Hosp, Dept Gastroenterol, 235 Euston Rd, London, England
[3] UCL, Dept Surg & Intervent Sci, London, England
来源：
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH | 2017年 / 6卷 / 05期
关键词：
Barrett's esophagus; cost-effectiveness; dysplasia; endoscopic procedures; health economics; RADIOFREQUENCY ABLATION; MANAGEMENT; ADENOCARCINOMA; SURVEILLANCE; ASSOCIATION; SURVIVAL; OUTCOMES; ESOPHAGECTOMY; PROGRESSION; RESECTION;
D O I：
10.2217/cer-2016-0089
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
Aim: The aim was to evaluate the cost-effectiveness of endoscopic eradication therapy (EET) with combined endoscopic mucosal resection and radiofrequency ablation for the treatment of high-grade dysplasia (HGD) arising in patients with Barrett's esophagus compared with endoscopic surveillance alone in the UK. Materials & methods: The cost-effectiveness model consisted of a decision tree and modified Markov model. A lifetime time horizon was adopted with the perspective of the UK healthcare system. Results: The base case analysis estimates that EET for the treatment of HGD is cost-effective at a GB pound 20,000 cost-effectiveness threshold compared with providing surveillance alone for HGD patients (incremental cost-effectiveness ratio: GB alpha 1272). Conclusion: EET is likely to be a cost-effective treatment strategy compared with surveillance alone in patients with HGD arising in Barrett's esophagus in the UK.
引用
收藏
页码：425 / 436
页数：12
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