Successful implementation of automation in medicinal chemistry

被引：17

作者：

Coates, WJ ^{[1
]}

Hunter, DJ ^{[1
]}

MacLachlan, WS ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Combinatorial & Chem Technol, Harlow CM19 5AW, Essex, England

来源：

DRUG DISCOVERY TODAY | 2000年 / 5卷 / 11期

关键词：

D O I：

10.1016/S1359-6446(00)01571-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Automation in medicinal chemistry is often seen simply as a part of the combinatorial chemistry technologies used to meet the need for large, diverse screening collections for lead generation. However, the application of automation to the lead optimization phase of drug discovery offers the prospect of reduced cycle times via increased efficiency in target compound preparation. The realization of this goal requires the integration of efficient processes with equipment capable of delivering quality compounds and, of course, the skilled medicinal chemists.

引用

页码：521 / 527

页数：7

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