New photosensitizers of bacteriochlorin series for photodynamic cancer therapy

被引：12
作者：
Mironov, AF
Grin, MA
Tsiprovskii, AG
Segenevich, AV
Dzardanov, DV
Golovin, KV
Tsygankov, AA
Shim, YK
机构：
[1] Lomonosov State Acad Fine Chem Technol, Moscow 119571, Russia
[2] Russian Acad Sci, Inst Fundamental Problems Biol, Pushchino 142292, Moscow Oblast, Russia
[3] Korea Res Inst Chem Technol, Taejon 305343, South Korea
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2003年 / 29卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
bacteriochlorin p glutarimides; bacteriochlorophyll a; bacteriopurpurin; photodynamic therapy; photosensitizers; 3-vinylbacteriopurpurin;
D O I：
10.1023/A:1023272718636
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New derivatives of bacteriochlorophyll a hearing an extra glutarimide exocycle were synthesized, and their reactivity was studied. Acetyl group in 3-acetyl-2,7,12,18-tetramethyl-8-ethyl-13,15-dicarboxy-17,carboxyethyl-7,8,17,18-tetrahydroporphyrin (bacteriochlorin p) was chemically modified into alpha-hydroxyethyl and vinyl groups. A simple method of preparation of vinylbacteriopurpurin esters under the catalysis by p-toluenesulfonic acid was proposed. The resulting compounds exhibit a high adsorption in the visible and near IR areas of electronic spectra, a reasonable stability, and amphiphilic properties and, therefore, may be regarded as promising photosensitizers for the photodynamic cancer therapy.
引用
收藏
页码：190 / 197
页数：8
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