New photosensitizers of bacteriochlorin series for photodynamic cancer therapy

被引：12

作者：

Mironov, AF

Grin, MA

Tsiprovskii, AG

Segenevich, AV

Dzardanov, DV

Golovin, KV

Tsygankov, AA

Shim, YK

机构：

[1] Lomonosov State Acad Fine Chem Technol, Moscow 119571, Russia

[2] Russian Acad Sci, Inst Fundamental Problems Biol, Pushchino 142292, Moscow Oblast, Russia

[3] Korea Res Inst Chem Technol, Taejon 305343, South Korea

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2003年 / 29卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

bacteriochlorin p glutarimides; bacteriochlorophyll a; bacteriopurpurin; photodynamic therapy; photosensitizers; 3-vinylbacteriopurpurin;

D O I：

10.1023/A:1023272718636

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New derivatives of bacteriochlorophyll a hearing an extra glutarimide exocycle were synthesized, and their reactivity was studied. Acetyl group in 3-acetyl-2,7,12,18-tetramethyl-8-ethyl-13,15-dicarboxy-17,carboxyethyl-7,8,17,18-tetrahydroporphyrin (bacteriochlorin p) was chemically modified into alpha-hydroxyethyl and vinyl groups. A simple method of preparation of vinylbacteriopurpurin esters under the catalysis by p-toluenesulfonic acid was proposed. The resulting compounds exhibit a high adsorption in the visible and near IR areas of electronic spectra, a reasonable stability, and amphiphilic properties and, therefore, may be regarded as promising photosensitizers for the photodynamic cancer therapy.

引用

页码：190 / 197

页数：8

共 50 条

[21] Photobleaching of photosensitizers applied for photodynamic therapy
Stratonnikov, AA
Meerovich, GA
Loschenov, VB
OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY IX, 2000, 1 : 81 - 91
[22] Recent advancement in photosensitizers for photodynamic therapy
Singh, Praveen P.
Sinha, Surabhi
Gahtori, Prashant
Mishra, D. N.
Pandey, Geetika
Srivastava, Vishal
DYES AND PIGMENTS, 2024, 229
[23] MIXED ACENANNELLATED METALLOTETRAAZAPORPHINS - A NEW CLASS OF AMPHIPHILIC PHOTOSENSITIZERS FOR THE PHOTODYNAMIC THERAPY OF CANCER
GASPARD, S
MARGARON, P
TEMPETE, C
THU, HTT
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1990, 4 (04) : 419 - 423
[24] Photodynamic therapy - mechanisms, photosensitizers and combinations
Kwiatkowski, Stanislaw
Knap, Bartosz
Przystupski, Dawid
Saczko, Jolanta
Kedzierska, Ewa
Knap-Czop, Karolina
Kotlinska, Jolanta
Michel, Olga
Kotowski, Krzysztof
Kulbacka, Julita
BIOMEDICINE & PHARMACOTHERAPY, 2018, 106 : 1098 - 1107
[25] Application of Peptide-Conjugated Photosensitizers for Photodynamic Cancer Therapy: A Review
Vale, Nuno
Ramos, Raquel
Cruz, Ines
Pereira, Mariana
ORGANICS, 2024, 5 (04): : 429 - 442
[26] Photodynamic therapy of cancer: second and third generations of photosensitizers
Wohrle, D
Hirth, A
Bogdahn-Rai, T
Schnurpfeil, G
Shopova, M
RUSSIAN CHEMICAL BULLETIN, 1998, 47 (05) : 807 - 816
[27] Photodynamic Therapy of Oral Cancer and Novel Liposomal Photosensitizers
Duzgunes, Nejat
Piskorz, Jaroslaw
Skupin-Mrugalska, Paulina
Yildirim, Metin
Sessevmez, Melike
Cheung, Jennifer
ORAL, 2023, 3 (03): : 276 - 294
[28] An Overview of Potential Natural Photosensitizers in Cancer Photodynamic Therapy
Aziz, Bushra
Aziz, Iffat
Khurshid, Ahmat
Raoufi, Ehsan
Esfahani, Fahime Nasr
Jalilian, Zahra
Mozafari, M. R.
Taghavi, Elham
Ikram, Masroor
BIOMEDICINES, 2023, 11 (01)
[29] Recent Advances in Developing Photosensitizers for Photodynamic Cancer Therapy
Chen, Cong
Wang, Jianmin
Li, Xiaoyan
Liu, Xiaolong
Han, Xiao
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2017, 20 (05) : 414 - 422
[30] Metalloporphyrin–indomethacin conjugates as new photosensitizers for photodynamic therapy
Fengshou Wu
Mengqian Yang
Juan Zhang
Sizhe Zhu
Mengge Shi
Kai Wang
JBIC Journal of Biological Inorganic Chemistry, 2019, 24 : 53 - 60

← 1 2 3 4 5 →