New photosensitizers of bacteriochlorin series for photodynamic cancer therapy

被引：12

作者：

Mironov, AF

Grin, MA

Tsiprovskii, AG

Segenevich, AV

Dzardanov, DV

Golovin, KV

Tsygankov, AA

Shim, YK

机构：

[1] Lomonosov State Acad Fine Chem Technol, Moscow 119571, Russia

[2] Russian Acad Sci, Inst Fundamental Problems Biol, Pushchino 142292, Moscow Oblast, Russia

[3] Korea Res Inst Chem Technol, Taejon 305343, South Korea

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2003年 / 29卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

bacteriochlorin p glutarimides; bacteriochlorophyll a; bacteriopurpurin; photodynamic therapy; photosensitizers; 3-vinylbacteriopurpurin;

D O I：

10.1023/A:1023272718636

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New derivatives of bacteriochlorophyll a hearing an extra glutarimide exocycle were synthesized, and their reactivity was studied. Acetyl group in 3-acetyl-2,7,12,18-tetramethyl-8-ethyl-13,15-dicarboxy-17,carboxyethyl-7,8,17,18-tetrahydroporphyrin (bacteriochlorin p) was chemically modified into alpha-hydroxyethyl and vinyl groups. A simple method of preparation of vinylbacteriopurpurin esters under the catalysis by p-toluenesulfonic acid was proposed. The resulting compounds exhibit a high adsorption in the visible and near IR areas of electronic spectra, a reasonable stability, and amphiphilic properties and, therefore, may be regarded as promising photosensitizers for the photodynamic cancer therapy.

引用

页码：190 / 197

页数：8

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