MicroRNA Expression in Malignant Pleural Mesothelioma and Asbestosis: A Pilot Study

被引：29

作者：

Mozzoni, Paola ^{[1
]}

Ampollini, Luca ^{[2
]}

Goldoni, Matteo ^{[3
]}

Alinovi, Rossella ^{[3
]}

Tiseo, Marcello ^{[4
]}

Gnetti, Letizia ^{[5
]}

Carbognani, Paolo ^{[2
]}

Rusca, Michele ^{[2
]}

Mutti, Antonio ^{[3
]}

Percesepe, Antonio ^{[1
]}

Corradi, Massimo

机构：

[1] Univ Parma, Dept Med & Surg, Mol Genet, Parma, Italy

[2] Univ Parma, Dept Med & Surg, Thorac Surg, Parma, Italy

[3] Univ Parma, Dept Med & Surg, Parma, Italy

[4] Univ Hosp Parma, Med Oncol, Parma, Italy

[5] Univ Hosp Parma, Pathol Anat & Histol, Parma, Italy

来源：

DISEASE MARKERS | 2017年 / 2017卷

关键词：

COLORECTAL-CANCER CELLS; DOWN-REGULATION; LUNG-CANCER; TUMOR-SUPPRESSOR; GASTRIC-CANCER; VEGF-A; MIR-126; PROLIFERATION; CARCINOMA; CONTRIBUTES;

D O I：

10.1155/2017/9645940

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background. The identification of diagnostic/prognostic biomarkers for asbestos-related diseases is relevant for early diagnosis and patient survival and may contribute to understanding the molecular mechanisms underlying the disease development and progression. Aims. To identify a pattern of miRNAs as possible diagnostic biomarkers for patients with malignant pleural mesothelioma (MPM) and asbestosis (ASB) and as prognostic biomarkers for MPM patients. Methods. miRNA-16, miRNA-17, miRNA-126, and miRNA-486 were quantified in plasma and formalin-fixed paraffin- embedded samples to evaluate their diagnostic and prognostic roles compared to patients with other noncancerous pulmonary diseases (controls). Results. The expression of all the miRNAs was significantly lower in patients with MPM and ASB than that in controls. miRNA-16, miRNA-17, and miRNA-486 in plasma and tissue of MPM patients were significantly correlated. Furthermore, the expression of miRNA-16 in plasma and tissue, and miRNA-486 only in tissue, was positively related with cumulative survival in MPM patients. Conclusions. All the miRNA levels were decreased in patients with MPM or ASB, supporting the role of circulating miRNAs as a potential tool for diseases associated with exposure to asbestos fibers. miRNA-16 was directly related to MPM patient prognosis, suggesting its possible use as a prognostic marker in MPM patients.

引用

页数：10

共 81 条

[1] Are differentially expressed microRNAs useful in the diagnostics of malignant pleural mesothelioma? [J].