Bivalent CD19/CD20-Specific CAR T Cells with 4-1BB and Mutated CD28 Co-Stimulatory Domains Show Enhanced Function

被引：0
|
作者：
Roselli, Emiliano [1 ]
Li, Gongbo [1 ]
Spitler, Kristen [1 ]
Boucher, Justin [1 ]
Reid, Kayla M. [1 ]
Lee, Sae Bom [1 ]
Tu, Nhan [1 ]
Davila, Marco L. [1 ]
机构：
[1] H Lee Moffitt Canc Ctr & Res Inst, Immunol, Tampa, FL USA
来源：
MOLECULAR THERAPY | 2021年 / 29卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
146
引用
收藏
页码：74 / 75
页数：2
相关论文
共 50 条
  • [1] Phenotype and Function of SIV-Specific CAR T Cells with CD28 and 4-1BB Intracellular Signaling Domains
    Cartwright, Emily K.
    Pampusch, Mary S.
    Berger, Edward A.
    Rendhal, Aaron
    Skinner, Pamela J.
    MOLECULAR THERAPY, 2021, 29 (04) : 369 - 370
  • [2] Mutation of the CD28 Co-Stimulatory Domain Confers Enhanced CAR T Cell Function
    Boucher, Justin C.
    Li, Gongbo
    Kotani, Hiroshi
    Cabral, Maria
    Morrissey, Dylan
    Lee, Sae Bom
    Spitler, Kristen
    Beatty, Nolan
    Shrestha, Bishwas
    Yu, Bin
    Kazi, Aslamuzzaman
    Wang, Xuefeng
    Sebti, Said
    Davila, Marco L.
    BLOOD, 2019, 134
  • [3] Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand:: synergy with the CD28 co-stimulatory pathway
    Melero, I
    Bach, N
    Hellström, KE
    Aruffo, A
    Mittler, RS
    Chen, LP
    EUROPEAN JOURNAL OF IMMUNOLOGY, 1998, 28 (03) : 1116 - 1121
  • [4] Treatment of acute lymphoblastic leukaemia with the second generation of CD19 CAR-T containing either CD28 or 4-1BB
    Li, Shiqi
    Zhang, Jiasi
    Wang, Meiling
    Fu, Gang
    Li, Yunyan
    Pei, Li
    Xiong, Zhouxing
    Qin, Dabing
    Zhang, Rui
    Tian, Xiaobo
    Wei, Zhihao
    Chen, Run
    Chen, Xuejiao
    Wan, Jia
    Chen, Jun
    Wei, Xia
    Xu, Yanmin
    Zhang, Pei
    Wang, Ping
    Peng, Xi
    Yang, Sainan
    Shen, Junjie
    Yang, Zhi
    Chen, Jieping
    Qian, Cheng
    BRITISH JOURNAL OF HAEMATOLOGY, 2018, 181 (03) : 360 - 371
  • [5] CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results
    Till, Brian G.
    Jensen, Michael C.
    Wang, Jinjuan
    Qian, Xiaojun
    Gopal, Ajay K.
    Maloney, David G.
    Lindgren, Catherine G.
    Lin, Yukang
    Pagel, John M.
    Budde, Lihua E.
    Raubitschek, Andrew
    Forman, Stephen J.
    Greenberg, Philip D.
    Riddell, Stanley R.
    Press, Oliver W.
    BLOOD, 2012, 119 (17) : 3940 - 3950
  • [6] CD28/4-1BB CD123 CAR T cells in blastic plasmacytoid dendritic cell neoplasm
    Elodie Bôle-Richard
    Maxime Fredon
    Sabeha Biichlé
    François Anna
    Jean-Marie Certoux
    Florian Renosi
    Frédéric Tsé
    Chloé Molimard
    Séverine Valmary-Degano
    Alizée Jenvrin
    Walid Warda
    Jean-René Pallandre
    Francis Bonnefoy
    Margaux Poussard
    Marina Deschamps
    Tony Petrella
    Christophe Roumier
    Elizabeth Macintyre
    Frédéric Féger
    Eolia Brissot
    Mohamad Mohty
    Kiave-Yune HoWangYin
    Pierre Langlade-Demoyen
    Maria Loustau
    Julien Caumartin
    Yann Godet
    Delphine Binda
    Maïder Pagadoy
    Eric Deconinck
    Etienne Daguindau
    Philippe Saas
    Christophe Ferrand
    Fanny Angelot-Delettre
    Olivier Adotévi
    Francine Garnache-Ottou
    Leukemia, 2020, 34 : 3228 - 3241
  • [7] CD28/4-1BB CD123 CAR T cells in blastic plasmacytoid dendritic cell neoplasm
    Bole-Richard, Elodie
    Fredon, Maxime
    Biichle, Sabeha
    Anna, Francois
    Certoux, Jean-Marie
    Renosi, Florian
    Tse, Frederic
    Molimard, Chloe
    Valmary-Degano, Severine
    Jenvrin, Alizee
    Warda, Walid
    Pallandre, Jean-Rene
    Bonnefoy, Francis
    Poussard, Margaux
    Deschamps, Marina
    Petrella, Tony
    Roumier, Christophe
    Macintyre, Elizabeth
    Feger, Frederic
    Brissot, Eolia
    Mohty, Mohamad
    HoWangYin, Kiave-Yune
    Langlade-Demoyen, Pierre
    Loustau, Maria
    Caumartin, Julien
    Godet, Yann
    Binda, Delphine
    Pagadoy, Maider
    Deconinck, Eric
    Daguindau, Etienne
    Saas, Philippe
    Ferrand, Christophe
    Angelot-Delettre, Fanny
    Adotevi, Olivier
    Garnache-Ottou, Francine
    LEUKEMIA, 2020, 34 (12) : 3228 - 3241
  • [8] Role of IL-12 and 4-1BB ligand in cytokine production by CD28(+) and CD28(-) T cells
    Chu, NR
    DeBenedette, MA
    Stiernholm, BJN
    Barber, BH
    Watts, TH
    JOURNAL OF IMMUNOLOGY, 1997, 158 (07): : 3081 - 3089
  • [9] Pre-industrial production of a lentiviral vector for CD28/4-1BB CD123 CAR T cells
    Fournier, C.
    Biek, A.
    Bole-Richard, E.
    Nesarajah, A.
    Garnache-Ottou, F.
    Galy, A.
    HUMAN GENE THERAPY, 2024, 35 (3-4) : A226 - A227
  • [10] Costimulation of CD28(-) T lymphocytes by 4-1BB ligand
    DeBenedette, MA
    Shahinian, A
    Mak, TW
    Watts, TH
    JOURNAL OF IMMUNOLOGY, 1997, 158 (02): : 551 - 559
12345