G-protein β3 subunit (GNB3) gene polymorphisms and cardiovascular disease:: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study

被引：16

作者：

Renner, Wilfried

Hoffmann, Michael M.

Gruenbacher, Gerda

Winkelmann, Bernhard R.

Boehm, Bernhard O.

Maerz, Winfried

机构：

[1] Med Univ, Clin Inst Med & Chem Lab Diagnost, A-8036 Graz, Austria

[2] Univ Freiburg, Inst Clin Chem, Freiburg, Germany

[3] Frankfurt Sachsenhausen, Cardiol Grp, Frankfurt, Germany

[4] Univ Ulm, Div Endocrinol & Diabet, Ulm, Germany

[5] Synlab Ctr Lab Diagnost, Heidelberg, Germany

来源：

ATHEROSCLEROSIS | 2007年 / 192卷 / 01期

关键词：

coronary artery disease; myocardial infarction; genetic; risk factor;

D O I：

10.1016/j.atherosclerosis.2006.07.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A common 825C > T polymorphism in exon 10 of the gene for the beta-3 subunit of heterotrimeric G-proteins, GNB3, has been associated in some studies with traits of the metabolic syndrome as well as coronary artery disease (CAD), but these associations were refuted by other studies. To investigate the role of GNB3 gene variations in CAD and myocardial infarction (MI), we determined five GNB3 polymorphisms (-1429G > A, IVS5 + 41G > A, 657T > A, 814G > A and 825C > T) in the Ludwigshafen Risk and Cardiovascular Health (LURIC) cohort, including 2575 patients with angiographically documented CAD and 731 individuals in whom CAD had been ruled out by angiography. None of the GNB3 polymorphisms was associated with CAD, MI, diabetes, hypertension, blood pressure, body weight or body mass index. We conclude that a major contribution of GNB3 gene variants to CAD or MI risk is unlikely. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：108 / 112

页数：5

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