Ultrasound guidance versus the blind method for intrauterine catheter insemination: A randomized controlled trial

被引:4
作者
Mubarak, Sarah [1 ]
Yusoff, Noor Haliza [1 ]
Adnan, Tassha Hilda [2 ]
机构
[1] Gen Hosp Kuala Lumpur, Reprod Med Unit, Dept Obstet & Gynaecol, Jalan Pahang, Kuala Lumpur 50586, Malaysia
[2] Gen Hosp Kuala Lumpur, Natl Clin Res Ctr, Kuala Lumpur, Malaysia
来源
CLINICAL AND EXPERIMENTAL REPRODUCTIVE MEDICINE-CERM | 2019年 / 46卷 / 02期
关键词
Artificial insemination; Insemination; Pregnancy rates; Ultrasound; Visual analog pain scale; GUIDED ARTIFICIAL-INSEMINATION; EMBRYO-TRANSFER; OVARIAN STIMULATION; PREGNANCY;
D O I
10.5653/cerm.2019.46.2.87
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: The primary objective of this study was to compare clinical pregnancy rates in intrauterine insemination (IUI) treatment cycles with transabdominal ultrasound guidance during intrauterine catheter insemination (US-IUI) versus the "blind method" IUI without ultrasound guidance (BM-IUI). The secondary objective was to compare whether US-IUI had better patient tolerability and whether US-IUI made the insemination procedure easier for the clinician to perform compared to BM-IUI. Methods: This was a randomized controlled trial done at the Reproductive Medicine Unit of General Hospital Kuala Lumpur, Malaysia. We included women aged between 25 and 40 years who underwent an IUI treatment cycle with follicle-stimulating hormone injections for controlled ovarian stimulation. Results: A total of 130 patients were recruited for our study. The US-IUI group had 70 patients and the BM-IUI group had 60 patients. The clinical pregnancy rate was 10% in both groups (p > 0.995) and there were no significant difference between the groups for patient tolerability assessed by scores on a pain visual analog scale (p = 0.175) or level of difficulty for the clinician (p > 0.995). The multivariate analysis further showed no significant increase in the clinical pregnancy rate (adjusted odds ratio, 1.07; 95% confidence interval, 0.85-1.34; p = 0.558) in the US-IUI group compared to the BM-IUI group even after adjusting for potential covariates. Conclusion: The conventional blind method for intrauterine catheter insemination is recommended for patients undergoing IUI treatment. The use of ultrasound during the insemination procedure increased the need for trained personnel to perform ultrasonography and increased the cost, but added no extra benefits for patients or clinicians.
引用
收藏
页码:87 / 94
页数:8
相关论文
共 24 条
[11]  
Jain S., 2018, Eur. Med. J, V3, P58, DOI [10.33590/emj/10314775, DOI 10.33590/EMJ/10314775]
[12]   Effect of insemination timing on pregnancy outcome in association with female age, sperm motility, sperm morphology and sperm concentration in intrauterine insemination [J].
Lee, Jisun ;
Hwang, Suna ;
Lee, Jaehun ;
Yoo, Junghyun ;
Jang, Dongmin ;
Hwang, Kyungjoo ;
Kim, Miran .
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2018, 44 (06) :1100-1106
[13]   Techniques used for IUI: is it time for a change? [J].
Lemmens, L. ;
Kos, S. ;
Beijer, C. ;
Braat, D. D. M. ;
Nelen, W. L. D. M. ;
Wetzels, A. M. M. .
HUMAN REPRODUCTION, 2017, 32 (09) :1835-1845
[14]   Optimizing the technique of embryo transfer [J].
Mains, Lindsay ;
Van Voorhis, Bradley J. .
FERTILITY AND STERILITY, 2010, 94 (03) :785-790
[15]  
National Collaborating Centre for Women's and Children's Health (UK), 2013, FERT ASS TREATM PEOP
[16]  
Ombelet W, 2017, FACTS VIEWS VIS OBGY, V9, P131
[17]  
Organization WH, 2010, WHO LAB MAN EX PROC
[18]   Influence of ultrasound-guided artificial insemination on pregnancy rates: a randomized study [J].
Oruc, Ayla Sargin ;
Yilmaz, Nafiye ;
Gorkem, Umit ;
Inal, Hasan Ali ;
Seckin, Berna ;
Gulerman, Cavidan .
ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2014, 289 (01) :207-212
[19]   The Use of Ultrasound during Intrauterine Insemination in Unexplained Infertility May Improve Pregnancy Outcomes [J].
Oztekin, Deniz ;
Ozcinar, Emine ;
Kose, Can ;
Gulhan, Ibrahim ;
Ozeren, Mehmet ;
Tinar, Sivekar .
MEDICAL PRINCIPLES AND PRACTICE, 2013, 22 (03) :291-294
[20]  
Polat I, 2015, CLIN EXP OBSTET GYN, V42, P657