Pyridinium N-2′-pyridylaminide:: synthesis of 3-aryl-2-aminopyridines through an intramolecular radical process

被引：19
|
作者：
Sánchez, A [1 ]
Nuñez, A [1 ]
Alvarez-Builla, J [1 ]
Burgos, C [1 ]
机构：
[1] Univ Alcala De Henares, Dept Quim Organ, Madrid 28871, Spain
来源：
TETRAHEDRON | 2004年 / 60卷 / 51期
关键词：
arylation; biaryls; ipso-substitution mechanism; radicals and radical reaction; Tris(trimethylsilyl)silane;
D O I：
10.1016/j.tet.2004.09.099
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Tris(trimethylsilyl)silane (TTMSS) and azobisisobutironitrile (AIBN) promote the intramolecular heteroarylation of arenesulfonamides with pyridyl radicals under thermal conditions. The arenesulfonamides are easily prepared from pyridinium N-2'pyridylaminide. The heteroarylation process involves pyridyl radical cyclization and ipso substitution. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：11843 / 11850
页数：8
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