Behavioral and pharmacological description of oxaliplatin-induced painful neuropathy in rat

被引:117
作者
Ling, Bing
Authier, Nicolas
Balayssac, David
Eschalier, Alain
Coudore, Francois [1 ]
机构
[1] Univ Clermont1, Fac Pharm, Toxicol Lab, F-63001 Clermont Ferrand, France
[2] Fac Med & Pharm, U766, INSERM, F-63001 Clermont Ferrand, France
[3] CHU Clermont Ferrand, Serv Pharmacol, Hop G Montpied, F-63003 Clermont Ferrand, France
关键词
oxaliplatin; cold allodynia; cold hyperalgesia; mechanical allodynia; pharmacology;
D O I
10.1016/j.pain.2006.09.016
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
We describe an animal model of nociceptive sensory neuropathy induced by repeat intravenous administration of oxaliplatin in which treated animals partly reproduce the characteristic pain symptoms in oxaliplatin-treated patients. We tested the ability of 1, 2 and 4 mg/kg oxaliplatin doses injected twice-weekly for four-and-a-half consecutive weeks to induce a nociceptive peripheral neuropathy in male Sprague-Dawley rats. The behavioral assessment revealed cold allodynia (10 degrees C) and hyperalgesia (4 degrees C) symptoms associated with a mechanical allodynia. The rats maintained a good general clinical status without motor dysfunction. The 2 mg/kg oxaliplatin dose and the tail-immersion test in cold water (10 degrees C) were selected to compare pharmacological sensitivity between single administered drugs as morphine, lidocaine, carbamazepine, gabapentin and repeated administration of drugs as clomipramine, venlafaxine, calcium and magnesium solutions. Magnesium Solution (90 mg/kg) and venlafaxine (7.5 mg/kg) administration induced an antinociceptive effect whereas gabapentin (300 mg/kg), clomipramine (2.5 mg/kg) and lidocaine (3 and 6 mg/kg) only induced all antiallodynic effect. (c) 2006 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:225 / 234
页数:10
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