Indinavir population pharmacokinetics in plasma and cerebrospinal fluid

被引：44

作者：

Letendre, SL

Cappirelli, EV

Ellis, RJ

McCutchan, JA

机构：

[1] Univ Calif San Diego, HIV Neurobehav Res Ctr, San Diego, CA 92103 USA

[2] Univ Calif San Diego, Pediat Pharmacol Res Unit, San Diego, CA 92103 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 08期

关键词：

D O I：

10.1128/AAC.44.8.2173-2175.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Plasma and cerebrospinal fluid (CSF) indinavir concentrations were measured by high-performance liquid chromatography. The median concentration in plasma exceeded that in CSF 10-fold. The modeled CSF curve was flat at 155 nM, and the estimated ratio of the areas under the CSF and plasma concentration-time curves was 6%. We conclude that CSF indinavir concentrations are lower than levels in plasma but exceed the clinical 95% inhibitory concentration range.

引用

收藏

页码：2173 / 2175

页数：3

相关论文

共 14 条

[1] Failure to detect nelfinavir in the cerebrospinal fluid of HIV-1-infected patients with and without AIDS dementia complex [J].

Aweeka, F ;

Jayewardene, A ;

Staprans, S ;

Bellibas, SE ;

Kearney, B ;

Lizak, P ;

Novakovic-Agopian, T ;

Price, RW .

JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1999, 20 (01) :39-43

[2]

BEAL SL, 1992, NONMEN USER GUIDES

[3]

CHERUBIN CE, 1989, REV INFECT DIS, V11, P526

[4] Cerebrospinal fluid human immunodeficiency virus type 1 RNA levels are elevated in neurocognitively impaired individuals with acquired immunodeficiency syndrome [J].

Ellis, RJ ;

Hsia, K ;

Spector, SA ;

Nelson, JA ;

Heaton, RK ;

Wallace, MR ;

Abramson, I ;

Atkinson, JH ;

Grant, I ;

McCutchan, JA ;

Marcotte, T ;

Chandler, JL ;

Jernigan, T ;

Masliah, E ;

Abramson, I ;

Dupont, R .

ANNALS OF NEUROLOGY, 1997, 42 (05) :679-688

[5] Antiretroviral drugs and the central nervous system [J].

Enting, RH ;

Hoetelmans, RMW ;

Lange, JMA ;

Burger, DM ;

Beijnen, JH ;

Portegies, P .

AIDS, 1998, 12 (15) :1941-1955

[6] Cerebrospinal-fluid HIV-1 RNA and drug concentrations after treatment with lamivudine plus zidovudine or stavudine [J].

Foudraine, NA ;

Hoetelmans, RMW ;

Lange, JMA ;

de Wolf, F ;

van Benthem, BHB ;

Mass, JJ ;

Keet, IPM ;

Portegies, P .

LANCET, 1998, 351 (9115) :1547-1551

[7]

Kravcik S, 1999, J ACQ IMMUN DEF SYND, V21, P371

[8] Antibiotic pharmacodynamics in cerebrospinal fluid [J].

Lutsar, I ;

McCracken, GH ;

Friedland, IR .

CLINICAL INFECTIOUS DISEASES, 1998, 27 (05) :1117-1127

[9] Indinavir-based treatment of HIV-1 infected patients:: efficacy in the central nervous system [J].

Martin, C ;

Sönnerborg, A ;

Svensson, JO ;

Ståhle, L .

AIDS, 1999, 13 (10) :1227-1232

[10] Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain [J].

McArthur, JC ;

McClernon, DR ;

Cronin, MF ;

NanceSproson, TE ;

Saah, AJ ;

StClair, M ;

Lanier, ER .

ANNALS OF NEUROLOGY, 1997, 42 (05) :689-698