Phytochemicals from Camellia nitidissima Chi inhibited the formation of advanced glycation end-products by scavenging methylglyoxal

被引：66
|
作者：
Wang, Weixin [1 ,2 ]
Liu, Haiyan [2 ]
Wang, Zhennan [1 ]
Qi, Jing [1 ]
Yuan, Shengtao [3 ]
Zhang, Weijie [4 ]
Chen, Hongjuan [1 ]
Finley, John W. [5 ]
Gu, Liwei [2 ]
Jia, Ai-Qun [1 ]
机构：
[1] Nanjing Univ Sci & Technol, Sch Environm & Biol Engn, Nanjing 210094, Jiangsu, Peoples R China
[2] Univ Florida, Inst Food & Agr Sci, Dept Food Sci & Human Nutr, Gainesville, FL 32611 USA
[3] China Pharmaceut Univ, Jiangsu Ctr Pharmacodynam Res & Evaluat, Nanjing 210009, Jiangsu, Peoples R China
[4] Guangxi Gui RenTang Co Ltd, Fangchenggang 538021, Peoples R China
[5] Louisiana State Univ, Sch Nutr & Food Sci, Baton Rouge, LA USA
来源：
FOOD CHEMISTRY | 2016年 / 205卷
基金：
国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词：
Camellia nitidissima Chi; Quercetin; Advanced glycation end-products; Scavenging methylglyoxal; TRAPPING METHYLGLYOXAL; FLAVONOIDS; PROANTHOCYANIDINS; CONSTITUENTS; PHENOLS; AGES;
D O I：
10.1016/j.foodchem.2016.03.019
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The objective of this study was to investigate the inhibitory effects of Camellia nitidissima Chi (CNC) on the advanced glycation end-product (AGE) formation. CNC was extracted with ethanol and further separated into dichloromethane, ethyl acetate, n-butanol, and water soluble fractions. Ethyl acetate fraction had the highest total phenolic and quercetin content compared with other fractions. Sixteen phenolic compounds were identified using HPLC Triple TOF MS/MS. Bovine serum albumin (BSA)-glucose assay showed that dichloromethane and ethyl acetate fraction inhibited AGE formation by 88.1% and 87.5% at 2.5 mg/mL. BSA-methylglyoxal assay showed that ethyl acetate fraction inhibited 54.1% AGE formation while dichloromethane fraction inhibited 28.1%. Over 96.0% of methylglyoxal was scavenged by different fractions within 12 h. Both mono- and di-methylglyoxal quercetin adducts were identified after incubating quercetin with methylglyoxal using HPLC-ESI-MSn. The results in this study suggest that CNC extracts inhibited AGEs formation in part through scavenging methylglyoxal by phenolic compounds. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：204 / 211
页数：8
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