Synthesis and biological activity of some novel β-diketones containing pyrazole moiety

被引：0

作者：

Kumari, Neetu ^{[1
]}

Khandelwal, Poonam ^{[1
]}

Joshi, Y. C. ^{[2
]}

机构：

[1] Mohanlal Sukhadia Univ, Dept Chem, Udaipur 313001, Rajasthan, India

[2] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India

来源：

JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2014年 / 91卷 / 08期

关键词：

Acetophenone derivative; pyrazole-1-acetyl chloride; 1,3-diketones; sodium methoxide; antibacterial; antifungal activity; LIPID-PEROXIDATION; PHYTIC ACID; TANNIC-ACID; 1,3-DIKETONE; DERIVATIVES;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reaction of substituted pyrazole-l-acetyl chloride (3) with acetophenone derivative (4) in presence of sodium methoxide in dry toluene led to the synthesis of substituted beta-diketones containing pyrazole moiety (5a-l). All the newly synthesized compounds were confirmed by elemental analysis and IR, H-1, C-13 NMR and mass spectral studies. The compounds (5a-l) were evaluated for their antibacterial and antifungal activities.

引用

页码：1577 / 1582

页数：6

共 35 条

[1] Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of some new 2-[(2,6-dichloroanilino) phenyl]acetic acid derivatives
Amir, M
Shikha, K
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2004, 39 (06) : 535 - 545
[2] [Anonymous], 2003, CHEM HETEROCYCLES ST, DOI DOI 10.1002/352760183X
[3] [Anonymous], 2001, Pharm. Chem. J.
[4] Bebbington D., 2002, CHEM ABSTR, V137, P47221
[5] Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents
Bekhit, Adnan A.
Ashour, Hayam M. A.
Ghany, Yasser S. Abdel
Bekhit, Alaa El-Din A.
Baraka, Azza
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (03) : 456 - 463
[6] Bhagwan J., 1983, J I CHEM, V55, P58
[7] SYNTHESIS OF 3-SUBSTITUTED PENTANE-2,4-DIONES - VALUABLE INTERMEDIATES FOR LIQUID-CRYSTALS
CATIVIELA, C
SERRANO, JL
ZURBANO, MM
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (10) : 3074 - 3083
[8] Egg-Enweiler H. M., 2002, GER OFFEN CHEM ABSTR, V137, P47210
[9] Novel 1,3-dipropyl-8-(1-heteroarylmethyl-1H-pyrazol-4-yl)-xanthine derivatives as high affinity and selective A2B adenosine receptor antagonists
Elzein, E
Rao, KA
Li, XF
Perry, T
Parkhill, E
Palle, V
Varkhedkar, V
Gimbel, A
Zeng, DW
Lustig, D
Leung, K
Zablocki, J
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (02) : 302 - 306
[10] Novel 1,5-diphenylpyrazole nonnucleoside HIV-1 reverse transcriptase inhibitors with enhanced activity versus the delavirdine-resistant P236L mutant: Lead identification and SAR of 3-and 4-substituted derivatives
Genin, MJ
Biles, C
Keiser, BJ
Poppe, SM
Swaney, SM
Tarpley, WG
Yagi, Y
Romero, DL
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (05) : 1034 - 1040

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