The Platelet Count in Cerebral Malaria, Is It Useful to the Clinician?

被引:17
作者
Chimalizeni, Yamikani [1 ]
Kawaza, Kondwani [1 ]
Taylor, Terrie [2 ]
Molyneux, Malcolm [3 ]
机构
[1] Coll Med, Dept Paediat, Blantyre 3, Malawi
[2] Blantyre Malaria Project, Blantyre, Malawi
[3] Coll Med, Malawi LiverpoolWellcome Trust Clin Res Programme, Blantyre 3, Malawi
关键词
FALCIPARUM-MALARIA; CHILDREN; THROMBOCYTOPENIA; TRANSMISSION; BLOOD; CELLS;
D O I
10.4269/ajtmh.2010.09-0614
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
We conducted this study to determine the prognostic significance of the platelet count in children with cerebral malaria. We studied children with cerebral malaria admitted to the pediatric research ward at Queen Elizabeth Central Hospital, Malawi. We analyzed 1,811 children with cerebral malaria and compared them with 521 children with bacterial meningitis. There was a significant difference in platelet counts between children with cerebral malaria and those with meningitis. Among children with cerebral malaria, there was no relationship between the platelet count and either the admission coma score or the eventual outcome. Those with malarial retinopathy were more thrombocytopenic than those without. Our results suggest that the platelet count is not prognostic in Malawian children with cerebral malaria.
引用
收藏
页码:48 / 50
页数:3
相关论文
共 13 条
[1]   Malarial retinopathy: A newly established diagnostic sign in severe malaria [J].
Beare, Nicholas A. V. ;
Taylor, Terrie E. ;
Harding, Simon P. ;
Lewallen, Susan ;
Molyneux, Malcolm E. .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2006, 75 (05) :790-797
[2]   Prognostic value of thrombocytopenia in African children with falciparum malaria [J].
Gérardin, P ;
Rogier, C ;
Ka, AS ;
Jouvencel, P ;
Brousse, V ;
Imbert, P .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2002, 66 (06) :686-691
[3]   Platelet accumulation in brain microvessels in fatal pediatric cerebral malaria [J].
Grau, GE ;
Mackenzie, CD ;
Carr, RA ;
Redard, M ;
Pizzolato, G ;
Allasia, C ;
Cataldo, C ;
Taylor, TE ;
Molyneux, ME .
JOURNAL OF INFECTIOUS DISEASES, 2003, 187 (03) :461-466
[4]   IMMUNE-MEDIATED THROMBOCYTOPENIA OF MALARIA [J].
KELTON, JG ;
KEYSTONE, J ;
MOORE, J ;
DENOMME, G ;
TOZMAN, E ;
GLYNN, M ;
NEAME, PB ;
GAULDIE, J ;
JENSEN, J .
JOURNAL OF CLINICAL INVESTIGATION, 1983, 71 (04) :832-836
[5]   Thrombopoietin in Plasmodium falciparum malaria [J].
Kreil, A ;
Wenisch, C ;
Brittenham, G ;
Looareesuwan, S ;
Peck-Radosavljevic, M .
BRITISH JOURNAL OF HAEMATOLOGY, 2000, 109 (03) :534-536
[6]   Changes in white blood cells and platelets in children with falciparum malaria: relationship to disease outcome [J].
Ladhani, S ;
Lowe, B ;
Cole, AO ;
Kowuondo, K ;
Newton, CRJC .
BRITISH JOURNAL OF HAEMATOLOGY, 2002, 119 (03) :839-847
[7]  
MOLYNEUX ME, 1989, Q J MED, V71, P441
[8]   Case definitions of clinical malaria under different transmission conditions in Kilifi District, Kenya [J].
Mwangi, TW ;
Ross, A ;
Snow, RW ;
Marsh, K .
JOURNAL OF INFECTIOUS DISEASES, 2005, 191 (11) :1932-1939
[9]   ABSENCE OF SEASONAL-VARIATION IN MALARIA PARASITEMIA IN AN AREA OF INTENSE SEASONAL TRANSMISSION [J].
SMITH, T ;
CHARLWOOD, JD ;
KIHONDA, J ;
MWANKUSYE, S ;
BILLINGSLEY, P ;
MEUWISSEN, J ;
LYIMO, E ;
TAKKEN, W ;
TEUSCHER, T ;
TANNER, M .
ACTA TROPICA, 1993, 54 (01) :55-72
[10]  
Taha K., 2007, Kuwait Medical Journal, V39, P262