Encapsulation of myoglobin in PEGylated polyion complex vesicles made from a pair of oppositely charged block lonomers: A physiologically available oxygen carrier

被引：183
作者：
Kishimura, Akihiro
Koide, Aya
Osada, Kensuke
Yamasaki, Yttichi
Kataoka, Kazunori
机构：
[1] Univ Tokyo, Dept Mat Engn, Bunkyo Ku, Tokyo 1138656, Japan
[2] Univ Tokyo, Ctr NanoBio Integrat, Grad Sch Engn, Bunkyo Ku, Tokyo 1138656, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 32期
关键词：
block copolymers; microreactors; proteins; self-assembly; vesicles;
D O I：
10.1002/anie.200701776
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) Take your PIC: Biologically active polyion complex vesicles (PICsomes) with encapsulated myoglobin (Mb) can be prepared by the self-assembly of a pair of oppositely charged block ionomers with polyethylene glycol (PEG) segments (see picture; metMb: metmyoglobin). The loaded Mb maintains reversible oxygenation even in the presence of trypsin. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：6085 / 6088
页数：4
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