Endocrine and metabolic changes in Anguilla anguilla L. following exposure to β-naphthoflavone -: a microsomal enzyme inducer

被引：29

作者：

Teles, M ^{[1
]}

Oliveira, M ^{[1
]}

Pacheco, M ^{[1
]}

Santos, MA ^{[1
]}

机构：

[1] Univ Aveiro, Dept Biol, P-3810193 Aveiro, Portugal

来源：

ENVIRONMENT INTERNATIONAL | 2005年 / 31卷 / 01期

关键词：

beta-naphthoflavone; plasma; endocrine;

D O I：

10.1016/j.envint.2004.07.003

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Anguilla anguilla L. were exposed during 24 and 48 h to 2.7 muM beta-naphthoflavone (BNF), a known microsomal enzyme inducer. The BNF effects on thyroid-stimulating hormone (TSH), free triiodothyronine (T3), free thyroxine (T4) and cortisol plasma levels were investigated. Alterations on plasma glucose and lactate levels were also measured as an indication of energy-mobilizing hormones alterations. BNF showed to be able to decrease significantly A. anguilla plasma T4 levels, whereas TSH, T3 and cortisol plasma remained constant. However, plasma glucose levels were significantly increased, demonstrating that intermediary metabolism has been affected. These results demonstrate that BNF a PAH-like compound alters the normal functioning of the hypothalamo-pituitary-thyroid (HPT) axis in A. anguilla. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：99 / 104

页数：6

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