Glycoconjugate vaccines and immune interference: A review

被引：210
作者：
Dagan, Ron [1 ,2 ]
Poolman, Jan [3 ]
Siegrist, Claire-Anne [4 ]
机构：
[1] Ben Gurion Univ Negev, Fac Hlth Sci, Pediat Infect Dis Unit, IL-84101 Beer Sheva, Israel
[2] Soroka Univ, Med Ctr, Beer Sheva, Israel
[3] GlaxoSmithKline Biol, B-1330 Rixensart, Belgium
[4] CMU 1, Ctr Vaccinol & Neonatal Immunol, CH-1211 Geneva, Switzerland
来源：
VACCINE | 2010年 / 28卷 / 34期
关键词：
Interference; Conjugate vaccines; Hib vaccines; Carrier-induced epitopic suppression; INFLUENZAE-TYPE-B; ACELLULAR PERTUSSIS-VACCINE; TOXOID CONJUGATE VACCINE; INDUCED EPITOPIC SUPPRESSION; MENINGITIDIS SEROGROUP-C; NONTYPABLE HAEMOPHILUS-INFLUENZAE; 7-VALENT PNEUMOCOCCAL CONJUGATE; DTPA-HBV-IPV; CAPSULAR POLYSACCHARIDE; HEPATITIS-B;
D O I：
10.1016/j.vaccine.2010.06.026
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Bacterial polysaccharide-protein conjugate vaccines (Haemophilus influenzae type b [Hib], pneumococcal and meningococcal conjugates) have revolutionized pediatric vaccination strategies. The widely used carrier proteins are tetanus toxoid (TT), diphtheria toxoid (DT) and diphtheria toxoid variant CRM197 protein, DT conjugates being in general less immunogenic. Multivalent conjugates using TT were found to be at risk for reduced polysaccharide responses, whilst multivalent CRM197 conjugates are at lower risk for this, but may be at higher risk of inducing bystander interference, particularly affecting Hib and hepatitis B immune responses. Novel carriers avoiding these issues could enable the further development of pediatric schedules and combinations. (C) 2010 Elsevier Ltd. All rights reserved.
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收藏
页码：5513 / 5523
页数：11
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