1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione

被引：1

作者：

Pardali, Vasiliki ^{[1
]}

Katsamakas, Sotirios ^{[1
]}

Giannakopoulou, Erofili ^{[1
]}

Zoidis, Grigoris ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Div Pharmaceut Chem, Athens 15771, Greece

来源：

MOLBANK | 2021年 / 2021卷 / 02期

关键词：

carbocyclic hydantoins; N-1 substituted hydantoin; spiro hydantoins; imidazolidine-2,4-diones; DFT calculations; stereochemistry; NMR; HRMS; GIAO; ring closing; SPIN COUPLING-CONSTANTS; 2ND ROW ATOMS; BASIS-SET; PERTURBATION-THEORY; HYDANTOIN; INHIBITORS; ANALOGS; III; 1ST;

D O I：

10.3390/M1228

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, fast and cost-effective three-step synthesis of 1-methyl-8-phenyl-1,3-diazaspiro[4.5] decane-2,4-dione has been developed. The reactions described herein proceed readily, with high yields and no further purification. Therefore, the proposed method, with an overall yield of 60%, offers a facile pathway to the synthesis of N-1 monosubstituted spiro carbocyclic imidazolidine-2,4-diones (hydantoins), which constitute a privileged class of heterocyclic scaffolds with pharmacological interest.

引用

页数：7